Deorukhkar AA - Search Results

1

Exploiting Arginine Auxotrophy with Pegylated Arginine Deiminase (ADI-PEG20) to Sensitize Pancreatic Cancer to Radiotherapy via Metabolic Dysregulation.

Singh PK, Deorukhkar AA, Venkatesulu BP, Li X, Tailor R, Bomalaski JS, Krishnan S. Singh PK, et al. Among authors: deorukhkar aa. Mol Cancer Ther. 2019 Dec;18(12):2381-2393. doi: 10.1158/1535-7163.MCT-18-0708. Epub 2019 Aug 8. Mol Cancer Ther. 2019. PMID: 31395686 Free PMC article.

2

A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo.

Harikumar KB, Kunnumakkara AB, Ochi N, Tong Z, Deorukhkar A, Sung B, Kelland L, Jamieson S, Sutherland R, Raynham T, Charles M, Bagherzadeh A, Foxton C, Boakes A, Farooq M, Maru D, Diagaradjane P, Matsuo Y, Sinnett-Smith J, Gelovani J, Krishnan S, Aggarwal BB, Rozengurt E, Ireson CR, Guha S. Harikumar KB, et al. Mol Cancer Ther. 2010 May;9(5):1136-46. doi: 10.1158/1535-7163.MCT-09-1145. Epub 2010 May 4. Mol Cancer Ther. 2010. PMID: 20442301 Free PMC article.

3

Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model.

Kunnumakkara AB, Diagaradjane P, Anand P, Harikumar KB, Deorukhkar A, Gelovani J, Guha S, Krishnan S, Aggarwal BB. Kunnumakkara AB, et al. Int J Cancer. 2009 Nov 1;125(9):2187-97. doi: 10.1002/ijc.24593. Int J Cancer. 2009. PMID: 19623659

4

Targeting inflammatory pathways for tumor radiosensitization.

Deorukhkar A, Krishnan S. Deorukhkar A, et al. Biochem Pharmacol. 2010 Dec 15;80(12):1904-14. doi: 10.1016/j.bcp.2010.06.039. Epub 2010 Jun 30. Biochem Pharmacol. 2010. PMID: 20599771 Free PMC article. Review.

5

{Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment.

Kunnumakkara AB, Sung B, Ravindran J, Diagaradjane P, Deorukhkar A, Dey S, Koca C, Yadav VR, Tong Z, Gelovani JG, Guha S, Krishnan S, Aggarwal BB. Kunnumakkara AB, et al. Cancer Res. 2010 Nov 1;70(21):8695-705. doi: 10.1158/0008-5472.CAN-10-2318. Epub 2010 Sep 23. Cancer Res. 2010. PMID: 20864511 Free PMC article.

6

Zerumbone increases oxidative stress in a thiol-dependent ROS-independent manner to increase DNA damage and sensitize colorectal cancer cells to radiation.

Deorukhkar A, Ahuja N, Mercado AL, Diagaradjane P, Raju U, Patel N, Mohindra P, Diep N, Guha S, Krishnan S. Deorukhkar A, et al. Cancer Med. 2015 Feb;4(2):278-92. doi: 10.1002/cam4.367. Epub 2014 Dec 1. Cancer Med. 2015. PMID: 25450478 Free PMC article.

7

Selective EGLN Inhibition Enables Ablative Radiotherapy and Improves Survival in Unresectable Pancreatic Cancer.

Fujimoto TN, Colbert LE, Huang Y, Molkentine JM, Deorukhkar A, Baseler L, de la Cruz Bonilla M, Yu M, Lin D, Gupta S, Cabeceiras PK, Kingsley CV, Tailor RC, Sawakuchi GO, Koay EJ, Piwnica-Worms H, Maitra A, Taniguchi CM. Fujimoto TN, et al. Cancer Res. 2019 May 1;79(9):2327-2338. doi: 10.1158/0008-5472.CAN-18-1785. Cancer Res. 2019. PMID: 31043430 Free PMC article.

8

Inhibition of radiation-induced DNA repair and prosurvival pathways contributes to vorinostat-mediated radiosensitization of pancreatic cancer cells.

Deorukhkar A, Shentu S, Park HC, Diagaradjane P, Puduvalli V, Aggarwal B, Guha S, Krishnan S. Deorukhkar A, et al. Pancreas. 2010 Nov;39(8):1277-83. doi: 10.1097/MPA.0b013e3181dd63e1. Pancreas. 2010. PMID: 20531243 Free PMC article.

9

Back to basics: how natural products can provide the basis for new therapeutics.

Deorukhkar A, Krishnan S, Sethi G, Aggarwal BB. Deorukhkar A, et al. Expert Opin Investig Drugs. 2007 Nov;16(11):1753-73. doi: 10.1517/13543784.16.11.1753. Expert Opin Investig Drugs. 2007. PMID: 17970636 Review.

10

Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products.

Kunnumakkara AB, Diagaradjane P, Guha S, Deorukhkar A, Shentu S, Aggarwal BB, Krishnan S. Kunnumakkara AB, et al. Clin Cancer Res. 2008 Apr 1;14(7):2128-36. doi: 10.1158/1078-0432.CCR-07-4722. Clin Cancer Res. 2008. PMID: 18381954

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