Ding L - Search Results

1

Development of the triazole-fused pyrimidine derivatives as highly potent and reversible inhibitors of histone lysine specific demethylase 1 (LSD1/KDM1A).

Li Z, Ding L, Li Z, Wang Z, Suo F, Shen D, Zhao T, Sun X, Wang J, Liu Y, Ma L, Zhao B, Geng P, Yu B, Zheng Y, Liu H. Li Z, et al. Among authors: ding l. Acta Pharm Sin B. 2019 Jul;9(4):794-808. doi: 10.1016/j.apsb.2019.01.001. Epub 2019 Jan 5. Acta Pharm Sin B. 2019. PMID: 31384539 Free PMC article.

2

Design, synthesis, and structure-activity relationship of novel LSD1 inhibitors based on pyrimidine-thiourea hybrids as potent, orally active antitumor agents.

Ma LY, Zheng YC, Wang SQ, Wang B, Wang ZR, Pang LP, Zhang M, Wang JW, Ding L, Li J, Wang C, Hu B, Liu Y, Zhang XD, Wang JJ, Wang ZJ, Zhao W, Liu HM. Ma LY, et al. Among authors: ding l. J Med Chem. 2015 Feb 26;58(4):1705-16. doi: 10.1021/acs.jmedchem.5b00037. Epub 2015 Feb 6. J Med Chem. 2015. PMID: 25610955

3

Flavokawain A induces deNEDDylation and Skp2 degradation leading to inhibition of tumorigenesis and cancer progression in the TRAMP transgenic mouse model.

Li X, Yokoyama NN, Zhang S, Ding L, Liu HM, Lilly MB, Mercola D, Zi X. Li X, et al. Among authors: ding l. Oncotarget. 2015 Dec 8;6(39):41809-24. doi: 10.18632/oncotarget.6166. Oncotarget. 2015. PMID: 26497688 Free PMC article.

4

Pro-Apoptotic Effects of JDA-202, a Novel Natural Diterpenoid, on Esophageal Cancer Through Targeting Peroxiredoxin I.

Shi XJ, Ding L, Zhou W, Ji Y, Wang J, Wang H, Ma Y, Jiang G, Tang K, Ke Y, Zhao W, Liu HM. Shi XJ, et al. Among authors: ding l. Antioxid Redox Signal. 2017 Jul 10;27(2):73-92. doi: 10.1089/ars.2016.6703. Epub 2016 Nov 1. Antioxid Redox Signal. 2017. PMID: 27650197 Free PMC article.

5

Discovery of resveratrol derivatives as novel LSD1 inhibitors: Design, synthesis and their biological evaluation.

Duan YC, Guan YY, Zhai XY, Ding LN, Qin WP, Shen DD, Liu XQ, Sun XD, Zheng YC, Liu HM. Duan YC, et al. Eur J Med Chem. 2017 Jan 27;126:246-258. doi: 10.1016/j.ejmech.2016.11.035. Epub 2016 Nov 16. Eur J Med Chem. 2017. PMID: 27888721

6

3D-QSAR (CoMFA, CoMSIA), molecular docking and molecular dynamics simulations study of 6-aryl-5-cyano-pyrimidine derivatives to explore the structure requirements of LSD1 inhibitors.

Ding L, Wang ZZ, Sun XD, Yang J, Ma CY, Li W, Liu HM. Ding L, et al. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3521-3528. doi: 10.1016/j.bmcl.2017.05.065. Epub 2017 May 24. Bioorg Med Chem Lett. 2017. PMID: 28610981

7

Design and synthesis of tranylcypromine derivatives as novel LSD1/HDACs dual inhibitors for cancer treatment.

Duan YC, Ma YC, Qin WP, Ding LN, Zheng YC, Zhu YL, Zhai XY, Yang J, Ma CY, Guan YY. Duan YC, et al. Eur J Med Chem. 2017 Nov 10;140:392-402. doi: 10.1016/j.ejmech.2017.09.038. Epub 2017 Sep 21. Eur J Med Chem. 2017. PMID: 28987602

8

Probing the binding mechanism of substituted pyridine derivatives as effective and selective lysine-specific demethylase 1 inhibitors using 3D-QSAR, molecular docking and molecular dynamics simulations.

Wang ZZ, Yang J, Sun XD, Ma CY, Gao QB, Ding L, Liu HM. Wang ZZ, et al. Among authors: ding l. J Biomol Struct Dyn. 2019 Aug;37(13):3482-3495. doi: 10.1080/07391102.2018.1518158. Epub 2018 Dec 5. J Biomol Struct Dyn. 2019. PMID: 30175693

9

Identifying the novel inhibitors of lysine-specific demethylase 1 (LSD1) combining pharmacophore-based and structure-based virtual screening.

Sun XD, Zheng YC, Ma CY, Yang J, Gao QB, Yan Y, Wang ZZ, Li W, Zhao W, Liu HM, Ding L. Sun XD, et al. Among authors: ding l. J Biomol Struct Dyn. 2019 Oct;37(16):4200-4214. doi: 10.1080/07391102.2018.1538903. Epub 2018 Dec 5. J Biomol Struct Dyn. 2019. PMID: 30366512

10

Probing the binding mode and unbinding mechanism of LSD1 inhibitors by combined computational methods.

Sun X , Ding L , Liu HM . Sun X , et al. Among authors: ding l. Phys Chem Chem Phys. 2018 Dec 5;20(47):29833-29846. doi: 10.1039/c8cp03090a. Phys Chem Chem Phys. 2018. PMID: 30468219

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