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Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis.
Wellenstein MD, Coffelt SB, Duits DEM, van Miltenburg MH, Slagter M, de Rink I, Henneman L, Kas SM, Prekovic S, Hau CS, Vrijland K, Drenth AP, de Korte-Grimmerink R, Schut E, van der Heijden I, Zwart W, Wessels LFA, Schumacher TN, Jonkers J, de Visser KE. Wellenstein MD, et al. Among authors: jonkers j. Nature. 2019 Aug;572(7770):538-542. doi: 10.1038/s41586-019-1450-6. Epub 2019 Jul 31. Nature. 2019. PMID: 31367040 Free PMC article.
Conditional mouse models of sporadic cancer.
Jonkers J, Berns A. Jonkers J, et al. Nat Rev Cancer. 2002 Apr;2(4):251-65. doi: 10.1038/nrc777. Nat Rev Cancer. 2002. PMID: 12001987 Review.
Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis.
Derksen PW, Liu X, Saridin F, van der Gulden H, Zevenhoven J, Evers B, van Beijnum JR, Griffioen AW, Vink J, Krimpenfort P, Peterse JL, Cardiff RD, Berns A, Jonkers J. Derksen PW, et al. Among authors: jonkers j. Cancer Cell. 2006 Nov;10(5):437-49. doi: 10.1016/j.ccr.2006.09.013. Cancer Cell. 2006. PMID: 17097565 Free article.
Modeling metastatic breast cancer in mice.
Jonkers J, Derksen PW. Jonkers J, et al. J Mammary Gland Biol Neoplasia. 2007 Sep;12(2-3):191-203. doi: 10.1007/s10911-007-9050-8. J Mammary Gland Biol Neoplasia. 2007. PMID: 17587153 Free article. Review.
Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer.
Liu X, Holstege H, van der Gulden H, Treur-Mulder M, Zevenhoven J, Velds A, Kerkhoven RM, van Vliet MH, Wessels LF, Peterse JL, Berns A, Jonkers J. Liu X, et al. Among authors: jonkers j. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12111-6. doi: 10.1073/pnas.0702969104. Epub 2007 Jul 11. Proc Natl Acad Sci U S A. 2007. PMID: 17626182 Free PMC article.
Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer.
Rottenberg S, Nygren AO, Pajic M, van Leeuwen FW, van der Heijden I, van de Wetering K, Liu X, de Visser KE, Gilhuijs KG, van Tellingen O, Schouten JP, Jonkers J, Borst P. Rottenberg S, et al. Among authors: jonkers j. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12117-22. doi: 10.1073/pnas.0702955104. Epub 2007 Jul 11. Proc Natl Acad Sci U S A. 2007. PMID: 17626183 Free PMC article.
Large-scale mutagenesis in p19(ARF)- and p53-deficient mice identifies cancer genes and their collaborative networks.
Uren AG, Kool J, Matentzoglu K, de Ridder J, Mattison J, van Uitert M, Lagcher W, Sie D, Tanger E, Cox T, Reinders M, Hubbard TJ, Rogers J, Jonkers J, Wessels L, Adams DJ, van Lohuizen M, Berns A. Uren AG, et al. Among authors: jonkers j. Cell. 2008 May 16;133(4):727-41. doi: 10.1016/j.cell.2008.03.021. Cell. 2008. PMID: 18485879 Free PMC article.
358 results