Fosang A - Search Results

1

Adamts5^-/- Mice Exhibit Altered Aggrecan Proteolytic Profiles That Correlate With Ascending Aortic Anomalies.

Dupuis LE, Nelson EL, Hozik B, Porto SC, Rogers-DeCotes A, Fosang A, Kern CB. Dupuis LE, et al. Among authors: fosang a. Arterioscler Thromb Vasc Biol. 2019 Oct;39(10):2067-2081. doi: 10.1161/ATVBAHA.119.313077. Epub 2019 Aug 1. Arterioscler Thromb Vasc Biol. 2019. PMID: 31366218 Free PMC article.

2

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro.

Stanton H, Rogerson FM, East CJ, Golub SB, Lawlor KE, Meeker CT, Little CB, Last K, Farmer PJ, Campbell IK, Fourie AM, Fosang AJ. Stanton H, et al. Nature. 2005 Mar 31;434(7033):648-52. doi: 10.1038/nature03417. Nature. 2005. PMID: 15800625 Free article.

3

Evidence of a novel aggrecan-degrading activity in cartilage: Studies of mice deficient in both ADAMTS-4 and ADAMTS-5.

Rogerson FM, Stanton H, East CJ, Golub SB, Tutolo L, Farmer PJ, Fosang AJ. Rogerson FM, et al. Arthritis Rheum. 2008 Jun;58(6):1664-73. doi: 10.1002/art.23458. Arthritis Rheum. 2008. PMID: 18512787 Free article.

4

An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2.

Miller RE, Ishihara S, Tran PB, Golub SB, Last K, Miller RJ, Fosang AJ, Malfait AM. Miller RE, et al. Among authors: fosang aj. JCI Insight. 2018 Mar 22;3(6):e95704. doi: 10.1172/jci.insight.95704. JCI Insight. 2018. PMID: 29563338 Free PMC article.

5

ADAMTS-5 deficiency does not block aggrecanolysis at preferred cleavage sites in the chondroitin sulfate-rich region of aggrecan.

East CJ, Stanton H, Golub SB, Rogerson FM, Fosang AJ. East CJ, et al. J Biol Chem. 2007 Mar 23;282(12):8632-40. doi: 10.1074/jbc.M605750200. Epub 2007 Jan 25. J Biol Chem. 2007. PMID: 17255106 Free article.

6

ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo.

Little CB, Mittaz L, Belluoccio D, Rogerson FM, Campbell IK, Meeker CT, Bateman JF, Pritchard MA, Fosang AJ. Little CB, et al. Among authors: fosang aj. Arthritis Rheum. 2005 May;52(5):1461-72. doi: 10.1002/art.21022. Arthritis Rheum. 2005. PMID: 15880348 Free article.

7

ADAMTS-9 in Mouse Cartilage Has Aggrecanase Activity That Is Distinct from ADAMTS-4 and ADAMTS-5.

Rogerson FM, Last K, Golub SB, Gauci SJ, Stanton H, Bell KM, Fosang AJ. Rogerson FM, et al. Among authors: fosang aj. Int J Mol Sci. 2019 Jan 29;20(3):573. doi: 10.3390/ijms20030573. Int J Mol Sci. 2019. PMID: 30699963 Free PMC article.

8

Identifying the human aggrecanase.

Fosang AJ, Rogerson FM. Fosang AJ, et al. Osteoarthritis Cartilage. 2010 Sep;18(9):1109-16. doi: 10.1016/j.joca.2010.06.014. Epub 2010 Jul 13. Osteoarthritis Cartilage. 2010. PMID: 20633677 Free article. Review.

9

Drug insight: aggrecanases as therapeutic targets for osteoarthritis.

Fosang AJ, Little CB. Fosang AJ, et al. Nat Clin Pract Rheumatol. 2008 Aug;4(8):420-7. doi: 10.1038/ncprheum0841. Epub 2008 Jun 24. Nat Clin Pract Rheumatol. 2008. PMID: 18577998 Review.

10

Neoepitope antibodies against MMP-cleaved and aggrecanase-cleaved aggrecan.

Fosang AJ, Last K, Stanton H, Golub SB, Little CB, Brown L, Jackson DC. Fosang AJ, et al. Methods Mol Biol. 2010;622:312-47. doi: 10.1007/978-1-60327-299-5_19. Methods Mol Biol. 2010. PMID: 20135291

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