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TNFR1 membrane reorganization promotes distinct modes of TNFα signaling.
Morton PE, Perrin C, Levitt J, Matthews DR, Marsh RJ, Pike R, McMillan D, Maloney A, Poland S, Ameer-Beg S, Parsons M. Morton PE, et al. Among authors: mcmillan d. Sci Signal. 2019 Jul 30;12(592):eaaw2418. doi: 10.1126/scisignal.aaw2418. Sci Signal. 2019. PMID: 31363067
Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer.
O'Connell J, Porter J, Kroeplien B, Norman T, Rapecki S, Davis R, McMillan D, Arakaki T, Burgin A, Fox Iii D, Ceska T, Lecomte F, Maloney A, Vugler A, Carrington B, Cossins BP, Bourne T, Lawson A. O'Connell J, et al. Among authors: mcmillan d. Nat Commun. 2019 Dec 19;10(1):5795. doi: 10.1038/s41467-019-13616-1. Nat Commun. 2019. PMID: 31857588 Free PMC article.
A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF.
Lightwood DJ, Munro RJ, Porter J, McMillan D, Carrington B, Turner A, Scott-Tucker A, Hickford ES, Schmidt A, Fox D 3rd, Maloney A, Ceska T, Bourne T, O'Connell J, Lawson ADG. Lightwood DJ, et al. Among authors: mcmillan d. Nat Commun. 2021 Jan 25;12(1):583. doi: 10.1038/s41467-020-20825-6. Nat Commun. 2021. PMID: 33495445 Free PMC article.
Discovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling.
Adams R, Burnley RJ, Valenzano CR, Qureshi O, Doyle C, Lumb S, Del Carmen Lopez M, Griffin R, McMillan D, Taylor RD, Meier C, Mori P, Griffin LM, Wernery U, Kinne J, Rapecki S, Baker TS, Lawson AD, Wright M, Ettorre A. Adams R, et al. Among authors: mcmillan d. Sci Rep. 2017 Jan 30;7:37716. doi: 10.1038/srep37716. Sci Rep. 2017. PMID: 28134246 Free PMC article.
Detergent-free extraction of a functional low-expressing GPCR from a human cell line.
Bada Juarez JF, Muñoz-García JC, Inácio Dos Reis R, Henry A, McMillan D, Kriek M, Wood M, Vandenplas C, Sands Z, Castro L, Taylor R, Watts A. Bada Juarez JF, et al. Among authors: mcmillan d. Biochim Biophys Acta Biomembr. 2020 Mar 1;1862(3):183152. doi: 10.1016/j.bbamem.2019.183152. Epub 2019 Dec 13. Biochim Biophys Acta Biomembr. 2020. PMID: 31843475 Free article.
1,530 results