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What Should a Clinician Do When Spreading Depolarizations are Observed in a Patient?
Helbok R, Hartings JA, Schiefecker A, Balança B, Jewel S, Foreman B, Ercole A, Balu R, Ayata C, Ngwenya L, Rosenthal E, Boutelle MG, Farkas E, Dreier JP, Fabricius M, Shuttleworth CW, Carlson A. Helbok R, et al. Among authors: dreier jp. Neurocrit Care. 2020 Feb;32(1):306-310. doi: 10.1007/s12028-019-00777-6. Neurocrit Care. 2020. PMID: 31338747 Free PMC article.
Increased extracellular K+ concentration reduces the efficacy of N-methyl-D-aspartate receptor antagonists to block spreading depression-like depolarizations and spreading ischemia.
Petzold GC, Windmüller O, Haack S, Major S, Buchheim K, Megow D, Gabriel S, Lehmann TN, Drenckhahn C, Peters O, Meierkord H, Heinemann U, Dirnagl U, Dreier JP. Petzold GC, et al. Among authors: dreier jp. Stroke. 2005 Jun;36(6):1270-7. doi: 10.1161/01.STR.0000166023.51307.e0. Epub 2005 May 5. Stroke. 2005. PMID: 15879337
Spreading depolarizations occur in human ischemic stroke with high incidence.
Dohmen C, Sakowitz OW, Fabricius M, Bosche B, Reithmeier T, Ernestus RI, Brinker G, Dreier JP, Woitzik J, Strong AJ, Graf R; Co-Operative Study of Brain Injury Depolarisations (COSBID). Dohmen C, et al. Among authors: dreier jp. Ann Neurol. 2008 Jun;63(6):720-8. doi: 10.1002/ana.21390. Ann Neurol. 2008. PMID: 18496842
Association of seizures with cortical spreading depression and peri-infarct depolarisations in the acutely injured human brain.
Fabricius M, Fuhr S, Willumsen L, Dreier JP, Bhatia R, Boutelle MG, Hartings JA, Bullock R, Strong AJ, Lauritzen M. Fabricius M, et al. Among authors: dreier jp. Clin Neurophysiol. 2008 Sep;119(9):1973-84. doi: 10.1016/j.clinph.2008.05.025. Epub 2008 Jul 14. Clin Neurophysiol. 2008. PMID: 18621582 Free PMC article. Clinical Trial.
Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage.
Dreier JP, Major S, Manning A, Woitzik J, Drenckhahn C, Steinbrink J, Tolias C, Oliveira-Ferreira AI, Fabricius M, Hartings JA, Vajkoczy P, Lauritzen M, Dirnagl U, Bohner G, Strong AJ; COSBID study group. Dreier JP, et al. Brain. 2009 Jul;132(Pt 7):1866-81. doi: 10.1093/brain/awp102. Epub 2009 May 6. Brain. 2009. PMID: 19420089 Free PMC article.
250 results