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A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4.
Gilson PR, Kumarasingha R, Thompson J, Zhang X, Penington JS, Kalhor R, Bullen HE, Lehane AM, Dans MG, de Koning-Ward TF, Holien JK, Soares da Costa TP, Hulett MD, Buskes MJ, Crabb BS, Kirk K, Papenfuss AT, Cowman AF, Abbott BM. Gilson PR, et al. Among authors: bullen he. Sci Rep. 2019 Jul 16;9(1):10292. doi: 10.1038/s41598-019-46500-5. Sci Rep. 2019. PMID: 31311978 Free PMC article.
Proteomic analysis reveals novel proteins associated with the Plasmodium protein exporter PTEX and a loss of complex stability upon truncation of the core PTEX component, PTEX150.
Elsworth B, Sanders PR, Nebl T, Batinovic S, Kalanon M, Nie CQ, Charnaud SC, Bullen HE, de Koning Ward TF, Tilley L, Crabb BS, Gilson PR. Elsworth B, et al. Among authors: bullen he. Cell Microbiol. 2016 Nov;18(11):1551-1569. doi: 10.1111/cmi.12596. Epub 2016 May 3. Cell Microbiol. 2016. PMID: 27019089
Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity.
Gilson PR, Tan C, Jarman KE, Lowes KN, Curtis JM, Nguyen W, Di Rago AE, Bullen HE, Prinz B, Duffy S, Baell JB, Hutton CA, Jousset Subroux H, Crabb BS, Avery VM, Cowman AF, Sleebs BE. Gilson PR, et al. Among authors: bullen he. J Med Chem. 2017 Feb 9;60(3):1171-1188. doi: 10.1021/acs.jmedchem.6b01673. Epub 2017 Jan 26. J Med Chem. 2017. PMID: 28080063
Spatial organization of protein export in malaria parasite blood stages.
Charnaud SC, Jonsdottir TK, Sanders PR, Bullen HE, Dickerman BK, Kouskousis B, Palmer CS, Pietrzak HM, Laumaea AE, Erazo AB, McHugh E, Tilley L, Crabb BS, Gilson PR. Charnaud SC, et al. Among authors: bullen he. Traffic. 2018 Aug;19(8):605-623. doi: 10.1111/tra.12577. Epub 2018 May 23. Traffic. 2018. PMID: 29696751 Free article.
24 results