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Catalytic in vivo protein knockdown by small-molecule PROTACs.
Bondeson DP, Mares A, Smith IE, Ko E, Campos S, Miah AH, Mulholland KE, Routly N, Buckley DL, Gustafson JL, Zinn N, Grandi P, Shimamura S, Bergamini G, Faelth-Savitski M, Bantscheff M, Cox C, Gordon DA, Willard RR, Flanagan JJ, Casillas LN, Votta BJ, den Besten W, Famm K, Kruidenier L, Carter PS, Harling JD, Churcher I, Crews CM. Bondeson DP, et al. Among authors: crews cm. Nat Chem Biol. 2015 Aug;11(8):611-7. doi: 10.1038/nchembio.1858. Epub 2015 Jun 10. Nat Chem Biol. 2015. PMID: 26075522 Free PMC article.
Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging.
Gustafson JL, Neklesa TK, Cox CS, Roth AG, Buckley DL, Tae HS, Sundberg TB, Stagg DB, Hines J, McDonnell DP, Norris JD, Crews CM. Gustafson JL, et al. Among authors: crews cm. Angew Chem Int Ed Engl. 2015 Aug 10;54(33):9659-62. doi: 10.1002/anie.201503720. Epub 2015 Jun 17. Angew Chem Int Ed Engl. 2015. PMID: 26083457 Free PMC article.
Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL.
Lai AC, Toure M, Hellerschmied D, Salami J, Jaime-Figueroa S, Ko E, Hines J, Crews CM. Lai AC, et al. Among authors: crews cm. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):807-10. doi: 10.1002/anie.201507634. Epub 2015 Nov 23. Angew Chem Int Ed Engl. 2016. PMID: 26593377 Free PMC article.
Inducing Protein Degradation as a Therapeutic Strategy.
Crews CM, Georg G, Wang S. Crews CM, et al. J Med Chem. 2016 Jun 9;59(11):5129-30. doi: 10.1021/acs.jmedchem.6b00735. Epub 2016 May 20. J Med Chem. 2016. PMID: 27199030 No abstract available.
Targeted Protein Degradation by Small Molecules.
Bondeson DP, Crews CM. Bondeson DP, et al. Among authors: crews cm. Annu Rev Pharmacol Toxicol. 2017 Jan 6;57:107-123. doi: 10.1146/annurev-pharmtox-010715-103507. Epub 2016 Oct 12. Annu Rev Pharmacol Toxicol. 2017. PMID: 27732798 Free PMC article. Review.
193 results