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Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling.
Bosgra S, van de Steeg E, Vlaming ML, Verhoeckx KC, Huisman MT, Verwei M, Wortelboer HM. Bosgra S, et al. Among authors: van de steeg e. Eur J Pharm Sci. 2014 Dec 18;65:156-66. doi: 10.1016/j.ejps.2014.09.007. Epub 2014 Sep 28. Eur J Pharm Sci. 2014. PMID: 25261337
Proteomic Analysis of the Developmental Trajectory of Human Hepatic Membrane Transporter Proteins in the First Three Months of Life.
Mooij MG, van de Steeg E, van Rosmalen J, Windster JD, de Koning BA, Vaes WH, van Groen BD, Tibboel D, Wortelboer HM, de Wildt SN. Mooij MG, et al. Among authors: van rosmalen j, van groen bd, van de steeg e, de koning ba, de wildt sn. Drug Metab Dispos. 2016 Jul;44(7):1005-13. doi: 10.1124/dmd.115.068577. Epub 2016 Apr 21. Drug Metab Dispos. 2016. PMID: 27103634
Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes.
Wegler C, Gaugaz FZ, Andersson TB, Wiśniewski JR, Busch D, Gröer C, Oswald S, Norén A, Weiss F, Hammer HS, Joos TO, Poetz O, Achour B, Rostami-Hodjegan A, van de Steeg E, Wortelboer HM, Artursson P. Wegler C, et al. Among authors: van de steeg e. Mol Pharm. 2017 Sep 5;14(9):3142-3151. doi: 10.1021/acs.molpharmaceut.7b00364. Epub 2017 Aug 16. Mol Pharm. 2017. PMID: 28767254 Free article.
Development of a mechanistic biokinetic model for hepatic bile acid handling to predict possible cholestatic effects of drugs.
Notenboom S, Weigand KM, Proost JH, van Lipzig MMH, van de Steeg E, van den Broek PHH, Greupink R, Russel FGM, Groothuis GMM. Notenboom S, et al. Among authors: van den broek phh, van lipzig mmh, van de steeg e. Eur J Pharm Sci. 2018 Mar 30;115:175-184. doi: 10.1016/j.ejps.2018.01.007. Epub 2018 Jan 5. Eur J Pharm Sci. 2018. PMID: 29309877 Free article.
54 results