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Heterogeneous antiretroviral drug distribution and HIV/SHIV detection in the gut of three species.
Thompson CG, Rosen EP, Prince HMA, White N, Sykes C, de la Cruz G, Mathews M, Deleage C, Estes JD, Charlins P, Mulder LR, Kovarova M, Adamson L, Arora S, Dellon ES, Peery AF, Shaheen NJ, Gay C, Muddiman DC, Akkina R, Garcia JV, Luciw P, Kashuba ADM. Thompson CG, et al. Among authors: garcia jv. Sci Transl Med. 2019 Jul 3;11(499):eaap8758. doi: 10.1126/scitranslmed.aap8758. Sci Transl Med. 2019. PMID: 31270274 Free PMC article. Clinical Trial.
One percent tenofovir applied topically to humanized BLT mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the BLT model for evaluation of new microbicide candidates.
Denton PW, Othieno F, Martinez-Torres F, Zou W, Krisko JF, Fleming E, Zein S, Powell DA, Wahl A, Kwak YT, Welch BD, Kay MS, Payne DA, Gallay P, Appella E, Estes JD, Lu M, Garcia JV. Denton PW, et al. Among authors: garcia jv. J Virol. 2011 Aug;85(15):7582-93. doi: 10.1128/JVI.00537-11. Epub 2011 May 18. J Virol. 2011. PMID: 21593172 Free PMC article.
Generation of HIV latency in humanized BLT mice.
Denton PW, Olesen R, Choudhary SK, Archin NM, Wahl A, Swanson MD, Chateau M, Nochi T, Krisko JF, Spagnuolo RA, Margolis DM, Garcia JV. Denton PW, et al. Among authors: garcia jv. J Virol. 2012 Jan;86(1):630-4. doi: 10.1128/JVI.06120-11. Epub 2011 Oct 19. J Virol. 2012. PMID: 22013053 Free PMC article.
Targeted cytotoxic therapy kills persisting HIV infected cells during ART.
Denton PW, Long JM, Wietgrefe SW, Sykes C, Spagnuolo RA, Snyder OD, Perkey K, Archin NM, Choudhary SK, Yang K, Hudgens MG, Pastan I, Haase AT, Kashuba AD, Berger EA, Margolis DM, Garcia JV. Denton PW, et al. Among authors: garcia jv. PLoS Pathog. 2014 Jan;10(1):e1003872. doi: 10.1371/journal.ppat.1003872. Epub 2014 Jan 9. PLoS Pathog. 2014. PMID: 24415939 Free PMC article.
Nanoformulations of Rilpivirine for Topical Pericoital and Systemic Coitus-Independent Administration Efficiently Prevent HIV Transmission.
Kovarova M, Council OD, Date AA, Long JM, Nochi T, Belshan M, Shibata A, Vincent H, Baker CE, Thayer WO, Kraus G, Lachaud-Durand S, Williams P, Destache CJ, Garcia JV. Kovarova M, et al. Among authors: garcia jv. PLoS Pathog. 2015 Aug 13;11(8):e1005075. doi: 10.1371/journal.ppat.1005075. eCollection 2015 Aug. PLoS Pathog. 2015. PMID: 26271040 Free PMC article.
Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary.
Akkina R, Allam A, Balazs AB, Blankson JN, Burnett JC, Casares S, Garcia JV, Hasenkrug KJ, Kashanchi F, Kitchen SG, Klein F, Kumar P, Luster AD, Poluektova LY, Rao M, Sanders-Beer BE, Shultz LD, Zack JA. Akkina R, et al. Among authors: garcia jv. AIDS Res Hum Retroviruses. 2016 Feb;32(2):109-19. doi: 10.1089/AID.2015.0258. AIDS Res Hum Retroviruses. 2016. PMID: 26670361 Free PMC article.
246 results