Respective roles of hyaluronidases 1 and 2 in endogenous hyaluronan turnover.
Bourguignon V, Flamion B.
Bourguignon V, et al. Among authors: flamion b.
FASEB J. 2016 Jun;30(6):2108-14. doi: 10.1096/fj.201500178R. Epub 2016 Feb 17.
FASEB J. 2016.
PMID: 26887442
We conclude that: 1) HYAL1 and HYAL2 are both needed for tissue HA catabolism; 2) HYAL2 is required for high MW HA clearance in lymph nodes and plasma and for HA endocytosis by liver NPCs; and 3) the main role of HYAL1 is HA degradation within liver NPCs.-Bourguignon, V., Flam …
We conclude that: 1) HYAL1 and HYAL2 are both needed for tissue HA catabolism; 2) HYAL2 is required for high MW HA clearance in lymph nodes …