Santos WL - Search Results

1

Metabolic Adaptation of Airway Smooth Muscle Cells to an SPHK2 Substrate Precedes Cytostasis.

Blais-Lecours P, Laouafa S, Arias-Reyes C, Santos WL, Joseph V, Burgess JK, Halayko AJ, Soliz J, Marsolais D. Blais-Lecours P, et al. Among authors: santos wl. Am J Respir Cell Mol Biol. 2020 Jan;62(1):35-42. doi: 10.1165/rcmb.2018-0397OC. Am J Respir Cell Mol Biol. 2020. PMID: 31247144 Free PMC article.

2

Structure-activity relationship studies and in vivo activity of guanidine-based sphingosine kinase inhibitors: discovery of SphK1- and SphK2-selective inhibitors.

Patwardhan NN, Morris EA, Kharel Y, Raje MR, Gao M, Tomsig JL, Lynch KR, Santos WL. Patwardhan NN, et al. Among authors: santos wl. J Med Chem. 2015 Feb 26;58(4):1879-1899. doi: 10.1021/jm501760d. Epub 2015 Feb 13. J Med Chem. 2015. PMID: 25643074 Free PMC article.

3

Mechanism of sphingosine 1-phosphate clearance from blood.

Kharel Y, Huang T, Salamon A, Harris TE, Santos WL, Lynch KR. Kharel Y, et al. Among authors: santos wl. Biochem J. 2020 Mar 13;477(5):925-935. doi: 10.1042/BCJ20190730. Biochem J. 2020. PMID: 32065229 Free PMC article.

4

Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors.

Raje MR, Knott K, Kharel Y, Bissel P, Lynch KR, Santos WL. Raje MR, et al. Among authors: santos wl. Bioorg Med Chem. 2012 Jan 1;20(1):183-94. doi: 10.1016/j.bmc.2011.11.011. Epub 2011 Nov 15. Bioorg Med Chem. 2012. PMID: 22137932 Free PMC article.

5

Effect of alkyl chain length on sphingosine kinase 2 selectivity.

Knott K, Kharel Y, Raje MR, Lynch KR, Santos WL. Knott K, et al. Among authors: santos wl. Bioorg Med Chem Lett. 2012 Nov 15;22(22):6817-20. doi: 10.1016/j.bmcl.2012.01.050. Epub 2012 Jan 26. Bioorg Med Chem Lett. 2012. PMID: 22321213 Free PMC article.

6

Drugging sphingosine kinases.

Santos WL, Lynch KR. Santos WL, et al. ACS Chem Biol. 2015 Jan 16;10(1):225-33. doi: 10.1021/cb5008426. Epub 2014 Nov 19. ACS Chem Biol. 2015. PMID: 25384187 Free PMC article. Review.

7

Structure-activity relationship studies of the lipophilic tail region of sphingosine kinase 2 inhibitors.

Congdon MD, Childress ES, Patwardhan NN, Gumkowski J, Morris EA, Kharel Y, Lynch KR, Santos WL. Congdon MD, et al. Among authors: santos wl. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4956-4960. doi: 10.1016/j.bmcl.2015.03.041. Epub 2015 Mar 23. Bioorg Med Chem Lett. 2015. PMID: 25862200 Free PMC article.

8

Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels.

Kharel Y, Morris EA, Congdon MD, Thorpe SB, Tomsig JL, Santos WL, Lynch KR. Kharel Y, et al. Among authors: santos wl. J Pharmacol Exp Ther. 2015 Oct;355(1):23-31. doi: 10.1124/jpet.115.225862. Epub 2015 Aug 4. J Pharmacol Exp Ther. 2015. PMID: 26243740 Free PMC article.

9

The impact of sphingosine kinase inhibitor-loaded nanoparticles on bioelectrical and biomechanical properties of cancer cells.

Babahosseini H, Srinivasaraghavan V, Zhao Z, Gillam F, Childress E, Strobl JS, Santos WL, Zhang C, Agah M. Babahosseini H, et al. Among authors: santos wl. Lab Chip. 2016 Jan 7;16(1):188-98. doi: 10.1039/c5lc01201e. Epub 2015 Nov 26. Lab Chip. 2016. PMID: 26607223 Free PMC article.

10

Sphingosine kinase inhibitors: a review of patent literature (2006-2015).

Lynch KR, Thorpe SB, Santos WL. Lynch KR, et al. Among authors: santos wl. Expert Opin Ther Pat. 2016 Dec;26(12):1409-1416. doi: 10.1080/13543776.2016.1226282. Epub 2016 Aug 30. Expert Opin Ther Pat. 2016. PMID: 27539678 Free PMC article. Review.

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