Tyndale RF - Search Results

1

Pharmacogenomics of Nicotine Metabolism: Novel CYP2A6 and CYP2B6 Genetic Variation Patterns in Alaska Native and American Indian Populations.

Claw KG, Beans JA, Lee SB, Avey JP, Stapleton PA, Scherer SE, El-Boraie A, Tyndale RF, Nickerson DA, Dillard DA, Thummel KE, Robinson RF. Claw KG, et al. Among authors: tyndale rf. Nicotine Tob Res. 2020 May 26;22(6):910-918. doi: 10.1093/ntr/ntz105. Nicotine Tob Res. 2020. PMID: 31241144 Free PMC article.

2

A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes.

Messina ES, Tyndale RF, Sellers EM. Messina ES, et al. Among authors: tyndale rf. J Pharmacol Exp Ther. 1997 Sep;282(3):1608-14. J Pharmacol Exp Ther. 1997. PMID: 9316878

3

Canadian Native Indians exhibit unique CYP2A6 and CYP2C19 mutant allele frequencies.

Nowak MP, Sellers EM, Tyndale RF. Nowak MP, et al. Among authors: tyndale rf. Clin Pharmacol Ther. 1998 Oct;64(4):378-83. doi: 10.1016/S0009-9236(98)90068-6. Clin Pharmacol Ther. 1998. PMID: 9797794

4

Variable CYP2A6-mediated nicotine metabolism alters smoking behavior and risk.

Tyndale RF, Sellers EM. Tyndale RF, et al. Drug Metab Dispos. 2001 Apr;29(4 Pt 2):548-52. Drug Metab Dispos. 2001. PMID: 11259349

5

A common genetic defect in nicotine metabolism decreases risk for dependence and lowers cigarette consumption.

Tyndale RF, Pianezza ML, Sellers EM. Tyndale RF, et al. Nicotine Tob Res. 1999;1 Suppl 2:S63-7; discussion S69-70. doi: 10.1080/14622299050011831. Nicotine Tob Res. 1999. PMID: 11768189 Review.

This paper outlines how genetic variation in the CYP2A6 gene may protect individuals from becoming nicotine-dependent smokers, and if dependent, how impairment of the CYP2A6 gene function decreases the number of cigarettes consumed by smokers (Pianezza M, Sellers EM, Tyndale …

This paper outlines how genetic variation in the CYP2A6 gene may protect individuals from becoming nicotine-dependent smokers, and if depend …

6

Genetic variation in CYP2A6-mediated nicotine metabolism alters smoking behavior.

Tyndale RF, Sellers EM. Tyndale RF, et al. Ther Drug Monit. 2002 Feb;24(1):163-71. doi: 10.1097/00007691-200202000-00026. Ther Drug Monit. 2002. PMID: 11805739 Review.

7

CYP2A6 genetic variation and potential consequences.

Xu C, Goodz S, Sellers EM, Tyndale RF. Xu C, et al. Among authors: tyndale rf. Adv Drug Deliv Rev. 2002 Nov 18;54(10):1245-56. doi: 10.1016/s0169-409x(02)00065-0. Adv Drug Deliv Rev. 2002. PMID: 12406643 Review.

8

Down-regulation of hepatic nicotine metabolism and a CYP2A6-like enzyme in African green monkeys after long-term nicotine administration.

Schoedel KA, Sellers EM, Palmour R, Tyndale RF. Schoedel KA, et al. Among authors: tyndale rf. Mol Pharmacol. 2003 Jan;63(1):96-104. doi: 10.1124/mol.63.1.96. Mol Pharmacol. 2003. PMID: 12488541

9

Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain.

Miksys S, Lerman C, Shields PG, Mash DC, Tyndale RF. Miksys S, et al. Among authors: tyndale rf. Neuropharmacology. 2003 Jul;45(1):122-32. doi: 10.1016/s0028-3908(03)00136-9. Neuropharmacology. 2003. PMID: 12814665

10

The effect of methoxsalen on nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in vivo.

Sellers EM, Ramamoorthy Y, Zeman MV, Djordjevic MV, Tyndale RF. Sellers EM, et al. Among authors: tyndale rf. Nicotine Tob Res. 2003 Dec;5(6):891-9. doi: 10.1080/14622200310001615231. Nicotine Tob Res. 2003. PMID: 14668073 Clinical Trial.

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