Forman-Kay J - Search Results

1

Augmentation of Cystic Fibrosis Transmembrane Conductance Regulator Function in Human Bronchial Epithelial Cells via SLC6A14-Dependent Amino Acid Uptake. Implications for Treatment of Cystic Fibrosis.

Ahmadi S, Wu YS, Li M, Ip W, Lloyd-Kuzik A, Di Paola M, Du K, Xia S, Lew A, Bozoky Z, Forman-Kay J, Bear CE, Gonska T. Ahmadi S, et al. Am J Respir Cell Mol Biol. 2019 Dec;61(6):755-764. doi: 10.1165/rcmb.2019-0094OC. Am J Respir Cell Mol Biol. 2019. PMID: 31189070

2

CFTR regulatory region interacts with NBD1 predominantly via multiple transient helices.

Baker JM, Hudson RP, Kanelis V, Choy WY, Thibodeau PH, Thomas PJ, Forman-Kay JD. Baker JM, et al. Nat Struct Mol Biol. 2007 Aug;14(8):738-45. doi: 10.1038/nsmb1278. Epub 2007 Jul 29. Nat Struct Mol Biol. 2007. PMID: 17660831 Free PMC article.

3

Phosphorylation-dependent 14-3-3 protein interactions regulate CFTR biogenesis.

Liang X, Da Paula AC, Bozóky Z, Zhang H, Bertrand CA, Peters KW, Forman-Kay JD, Frizzell RA. Liang X, et al. Mol Biol Cell. 2012 Mar;23(6):996-1009. doi: 10.1091/mbc.E11-08-0662. Epub 2012 Jan 25. Mol Biol Cell. 2012. PMID: 22278744 Free PMC article.

4

Conformational changes relevant to channel activity and folding within the first nucleotide binding domain of the cystic fibrosis transmembrane conductance regulator.

Hudson RP, Chong PA, Protasevich II, Vernon R, Noy E, Bihler H, An JL, Kalid O, Sela-Culang I, Mense M, Senderowitz H, Brouillette CG, Forman-Kay JD. Hudson RP, et al. J Biol Chem. 2012 Aug 17;287(34):28480-94. doi: 10.1074/jbc.M112.371138. Epub 2012 Jun 21. J Biol Chem. 2012. PMID: 22722932 Free PMC article.

5

Dynamics intrinsic to cystic fibrosis transmembrane conductance regulator function and stability.

Chong PA, Kota P, Dokholyan NV, Forman-Kay JD. Chong PA, et al. Cold Spring Harb Perspect Med. 2013 Mar 1;3(3):a009522. doi: 10.1101/cshperspect.a009522. Cold Spring Harb Perspect Med. 2013. PMID: 23457292 Free PMC article. Review.

6

Structural changes of CFTR R region upon phosphorylation: a plastic platform for intramolecular and intermolecular interactions.

Bozoky Z, Krzeminski M, Chong PA, Forman-Kay JD. Bozoky Z, et al. FEBS J. 2013 Sep;280(18):4407-16. doi: 10.1111/febs.12422. Epub 2013 Jul 25. FEBS J. 2013. PMID: 23826884 Free PMC article. Review.

7

The ZIP5 ectodomain co-localizes with PrP and may acquire a PrP-like fold that assembles into a dimer.

Pocanschi CL, Ehsani S, Mehrabian M, Wille H, Reginold W, Trimble WS, Wang H, Yee A, Arrowsmith CH, Bozóky Z, Kay LE, Forman-Kay JD, Rini JM, Schmitt-Ulms G. Pocanschi CL, et al. PLoS One. 2013 Sep 6;8(9):e72446. doi: 10.1371/journal.pone.0072446. eCollection 2013. PLoS One. 2013. PMID: 24039764 Free PMC article.

8

Regulatory R region of the CFTR chloride channel is a dynamic integrator of phospho-dependent intra- and intermolecular interactions.

Bozoky Z, Krzeminski M, Muhandiram R, Birtley JR, Al-Zahrani A, Thomas PJ, Frizzell RA, Ford RC, Forman-Kay JD. Bozoky Z, et al. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4427-36. doi: 10.1073/pnas.1315104110. Epub 2013 Nov 4. Proc Natl Acad Sci U S A. 2013. PMID: 24191035 Free PMC article.

9

Deletion of Phenylalanine 508 in the First Nucleotide-binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator Increases Conformational Exchange and Inhibits Dimerization.

Chong PA, Farber PJ, Vernon RM, Hudson RP, Mittermaier AK, Forman-Kay JD. Chong PA, et al. J Biol Chem. 2015 Sep 18;290(38):22862-78. doi: 10.1074/jbc.M115.641134. Epub 2015 Jul 6. J Biol Chem. 2015. PMID: 26149808 Free PMC article.

10

Binding screen for cystic fibrosis transmembrane conductance regulator correctors finds new chemical matter and yields insights into cystic fibrosis therapeutic strategy.

Hall JD, Wang H, Byrnes LJ, Shanker S, Wang K, Efremov IV, Chong PA, Forman-Kay JD, Aulabaugh AE. Hall JD, et al. Protein Sci. 2016 Feb;25(2):360-73. doi: 10.1002/pro.2821. Epub 2016 Jan 12. Protein Sci. 2016. PMID: 26444971 Free PMC article.

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