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Regulation of K+ flow by a ring of negative charges in the outer pore of BKCa channels. Part I: Aspartate 292 modulates K+ conduction by external surface charge effect.
Haug T, Sigg D, Ciani S, Toro L, Stefani E, Olcese R. Haug T, et al. Among authors: stefani e. J Gen Physiol. 2004 Aug;124(2):173-84. doi: 10.1085/jgp.200308949. J Gen Physiol. 2004. PMID: 15277578 Free PMC article.
Exchanging the aspartate residue with asparagine in this sequence abolishes ionic conductance of the Shaker K+ channel (D447N) (Hurst, R.S., L. Toro, and E. Stefani. 1996. FEBS Lett. 388:59-65). In contrast, we found that the corresponding mutation (D292N) in the po …
Exchanging the aspartate residue with asparagine in this sequence abolishes ionic conductance of the Shaker K+ channel (D447N) (Hurst, R.S., …
Regulation of K+ flow by a ring of negative charges in the outer pore of BKCa channels. Part II: Neutralization of aspartate 292 reduces long channel openings and gating current slow component.
Haug T, Olcese R, Toro L, Stefani E. Haug T, et al. Among authors: stefani e. J Gen Physiol. 2004 Aug;124(2):185-97. doi: 10.1085/jgp.200308950. J Gen Physiol. 2004. PMID: 15277579 Free PMC article.
Neutralization of the aspartate near the selectivity filter in the GYGD pore sequence (D292N) of the voltage- and Ca(2+)-activated K+ channel (MaxiK, BKCa) does not prevent conduction like the corresponding mutation in Shaker channel, but profoundly affects major biophysical prop …
Neutralization of the aspartate near the selectivity filter in the GYGD pore sequence (D292N) of the voltage- and Ca(2+)-activated K+ channe …
MaxiK channel partners: physiological impact.
Lu R, Alioua A, Kumar Y, Eghbali M, Stefani E, Toro L. Lu R, et al. Among authors: stefani e. J Physiol. 2006 Jan 1;570(Pt 1):65-72. doi: 10.1113/jphysiol.2005.098913. Epub 2005 Oct 20. J Physiol. 2006. PMID: 16239267 Free PMC article. Review.
Intracellular BK(Ca) (iBK(Ca)) channels.
Singh H, Stefani E, Toro L. Singh H, et al. Among authors: stefani e. J Physiol. 2012 Dec 1;590(23):5937-47. doi: 10.1113/jphysiol.2011.215533. Epub 2012 Aug 28. J Physiol. 2012. PMID: 22930268 Free PMC article. Review.
Mitochondrial BKCa channel.
Balderas E, Zhang J, Stefani E, Toro L. Balderas E, et al. Among authors: stefani e. Front Physiol. 2015 Mar 31;6:104. doi: 10.3389/fphys.2015.00104. eCollection 2015. Front Physiol. 2015. PMID: 25873902 Free PMC article. Review.
596 results