O'Brien EJ - Search Results

1

Laboratory evolution reveals a two-dimensional rate-yield tradeoff in microbial metabolism.

Cheng C, O'Brien EJ, McCloskey D, Utrilla J, Olson C, LaCroix RA, Sandberg TE, Feist AM, Palsson BO, King ZA. Cheng C, et al. Among authors: o brien ej. PLoS Comput Biol. 2019 Jun 3;15(6):e1007066. doi: 10.1371/journal.pcbi.1007066. eCollection 2019 Jun. PLoS Comput Biol. 2019. PMID: 31158228 Free PMC article.

2

Use of adaptive laboratory evolution to discover key mutations enabling rapid growth of Escherichia coli K-12 MG1655 on glucose minimal medium.

LaCroix RA, Sandberg TE, O'Brien EJ, Utrilla J, Ebrahim A, Guzman GI, Szubin R, Palsson BO, Feist AM. LaCroix RA, et al. Appl Environ Microbiol. 2015 Jan;81(1):17-30. doi: 10.1128/AEM.02246-14. Epub 2014 Oct 10. Appl Environ Microbiol. 2015. PMID: 25304508 Free PMC article.

3

Computing the functional proteome: recent progress and future prospects for genome-scale models.

O'Brien EJ, Palsson BO. O'Brien EJ, et al. Curr Opin Biotechnol. 2015 Aug;34:125-34. doi: 10.1016/j.copbio.2014.12.017. Epub 2015 Jan 8. Curr Opin Biotechnol. 2015. PMID: 25576845 Free PMC article. Review.

4

Global Rebalancing of Cellular Resources by Pleiotropic Point Mutations Illustrates a Multi-scale Mechanism of Adaptive Evolution.

Utrilla J, O'Brien EJ, Chen K, McCloskey D, Cheung J, Wang H, Armenta-Medina D, Feist AM, Palsson BO. Utrilla J, et al. Cell Syst. 2016 Apr 27;2(4):260-71. doi: 10.1016/j.cels.2016.04.003. Epub 2016 Apr 27. Cell Syst. 2016. PMID: 27135538 Free PMC article.

5

Quantification and Classification of E. coli Proteome Utilization and Unused Protein Costs across Environments.

O'Brien EJ, Utrilla J, Palsson BO. O'Brien EJ, et al. PLoS Comput Biol. 2016 Jun 28;12(6):e1004998. doi: 10.1371/journal.pcbi.1004998. eCollection 2016 Jun. PLoS Comput Biol. 2016. PMID: 27351952 Free PMC article.

6

Literature mining supports a next-generation modeling approach to predict cellular byproduct secretion.

King ZA, O'Brien EJ, Feist AM, Palsson BO. King ZA, et al. Metab Eng. 2017 Jan;39:220-227. doi: 10.1016/j.ymben.2016.12.004. Epub 2016 Dec 13. Metab Eng. 2017. PMID: 27986597

7

COBRAme: A computational framework for genome-scale models of metabolism and gene expression.

Lloyd CJ, Ebrahim A, Yang L, King ZA, Catoiu E, O'Brien EJ, Liu JK, Palsson BO. Lloyd CJ, et al. Among authors: o brien ej. PLoS Comput Biol. 2018 Jul 5;14(7):e1006302. doi: 10.1371/journal.pcbi.1006302. eCollection 2018 Jul. PLoS Comput Biol. 2018. PMID: 29975681 Free PMC article.

8

The genetic basis for adaptation of model-designed syntrophic co-cultures.

Lloyd CJ, King ZA, Sandberg TE, Hefner Y, Olson CA, Phaneuf PV, O'Brien EJ, Sanders JG, Salido RA, Sanders K, Brennan C, Humphrey G, Knight R, Feist AM. Lloyd CJ, et al. Among authors: o brien ej. PLoS Comput Biol. 2019 Mar 1;15(3):e1006213. doi: 10.1371/journal.pcbi.1006213. eCollection 2019 Mar. PLoS Comput Biol. 2019. PMID: 30822347 Free PMC article.

9

Genome-scale models of metabolism and gene expression extend and refine growth phenotype prediction.

O'Brien EJ, Lerman JA, Chang RL, Hyduke DR, Palsson BØ. O'Brien EJ, et al. Mol Syst Biol. 2013 Oct 1;9:693. doi: 10.1038/msb.2013.52. Mol Syst Biol. 2013. PMID: 24084808 Free PMC article.

10

Deciphering Fur transcriptional regulatory network highlights its complex role beyond iron metabolism in Escherichia coli.

Seo SW, Kim D, Latif H, O'Brien EJ, Szubin R, Palsson BO. Seo SW, et al. Nat Commun. 2014 Sep 15;5:4910. doi: 10.1038/ncomms5910. Nat Commun. 2014. PMID: 25222563 Free PMC article.

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