Whitty A - Search Results

1

A Central Region of NF-κB Essential Modulator Is Required for IKKβ-Induced Conformational Change and for Signal Propagation.

Shaffer R, DeMaria AM, Kagermazova L, Liu Y, Babaei M, Caban-Penix S, Cervantes A, Jehle S, Makowski L, Gilmore TD, Whitty A, Allen KN. Shaffer R, et al. Among authors: whitty a. Biochemistry. 2019 Jul 2;58(26):2906-2920. doi: 10.1021/acs.biochem.8b01316. Epub 2019 Jun 18. Biochemistry. 2019. PMID: 31145594 Free PMC article.

2

Binding efficiency of protein-protein complexes.

Day ES, Cote SM, Whitty A. Day ES, et al. Among authors: whitty a. Biochemistry. 2012 Nov 13;51(45):9124-36. doi: 10.1021/bi301039t. Epub 2012 Nov 1. Biochemistry. 2012. PMID: 23088250 Free PMC article.

3

Comprehensive experimental and computational analysis of binding energy hot spots at the NF-κB essential modulator/IKKβ protein-protein interface.

Golden MS, Cote SM, Sayeg M, Zerbe BS, Villar EA, Beglov D, Sazinsky SL, Georgiadis RM, Vajda S, Kozakov D, Whitty A. Golden MS, et al. Among authors: whitty a. J Am Chem Soc. 2013 Apr 24;135(16):6242-56. doi: 10.1021/ja400914z. Epub 2013 Apr 10. J Am Chem Soc. 2013. PMID: 23506214 Free PMC article.

4

Mutation of nonessential cysteines shows that the NF-κB essential modulator forms a constitutive noncovalent dimer that binds IκB kinase-β with high affinity.

Cote SM, Gilmore TD, Shaffer R, Weber U, Bollam R, Golden MS, Glover K, Herscovitch M, Ennis T, Allen KN, Whitty A. Cote SM, et al. Among authors: whitty a. Biochemistry. 2013 Dec 23;52(51):9141-54. doi: 10.1021/bi401368r. Epub 2013 Dec 10. Biochemistry. 2013. PMID: 24266532 Free PMC article.

5

Disulfide-mediated stabilization of the IκB kinase binding domain of NF-κB essential modulator (NEMO).

Zhou L, Yeo AT, Ballarano C, Weber U, Allen KN, Gilmore TD, Whitty A. Zhou L, et al. Among authors: whitty a. Biochemistry. 2014 Dec 23;53(50):7929-44. doi: 10.1021/bi500920n. Epub 2014 Dec 8. Biochemistry. 2014. PMID: 25400026 Free PMC article.

6

Inhibition of Oncogenic Transcription Factor REL by the Natural Product Derivative Calafianin Monomer 101 Induces Proliferation Arrest and Apoptosis in Human B-Lymphoma Cell Lines.

Yeo AT, Chennamadhavuni S, Whitty A, Porco JA Jr, Gilmore TD. Yeo AT, et al. Among authors: whitty a. Molecules. 2015 Apr 23;20(5):7474-94. doi: 10.3390/molecules20057474. Molecules. 2015. PMID: 25915462 Free PMC article.

7

Ligand deconstruction: Why some fragment binding positions are conserved and others are not.

Kozakov D, Hall DR, Jehle S, Luo L, Ochiana SO, Jones EV, Pollastri M, Allen KN, Whitty A, Vajda S. Kozakov D, et al. Among authors: whitty a. Proc Natl Acad Sci U S A. 2015 May 19;112(20):E2585-94. doi: 10.1073/pnas.1501567112. Epub 2015 Apr 27. Proc Natl Acad Sci U S A. 2015. PMID: 25918377 Free PMC article.

8

Exploring the structural origins of cryptic sites on proteins.

Beglov D, Hall DR, Wakefield AE, Luo L, Allen KN, Kozakov D, Whitty A, Vajda S. Beglov D, et al. Among authors: whitty a. Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3416-E3425. doi: 10.1073/pnas.1711490115. Epub 2018 Mar 26. Proc Natl Acad Sci U S A. 2018. PMID: 29581267 Free PMC article.

9

Interaction Energetics and Druggability of the Protein-Protein Interaction between Kelch-like ECH-Associated Protein 1 (KEAP1) and Nuclear Factor Erythroid 2 Like 2 (Nrf2).

Zhong M, Lynch A, Muellers SN, Jehle S, Luo L, Hall DR, Iwase R, Carolan JP, Egbert M, Wakefield A, Streu K, Harvey CM, Ortet PC, Kozakov D, Vajda S, Allen KN, Whitty A. Zhong M, et al. Among authors: whitty a. Biochemistry. 2020 Feb 4;59(4):563-581. doi: 10.1021/acs.biochem.9b00943. Epub 2020 Jan 2. Biochemistry. 2020. PMID: 31851823 Free PMC article.

10

MEnTaT: A machine-learning approach for the identification of mutations to increase protein stability.

Muellers SN, Allen KN, Whitty A. Muellers SN, et al. Among authors: whitty a. Proc Natl Acad Sci U S A. 2023 Dec 5;120(49):e2309884120. doi: 10.1073/pnas.2309884120. Epub 2023 Dec 1. Proc Natl Acad Sci U S A. 2023. PMID: 38039271 Free PMC article.

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