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DamC reveals principles of chromatin folding in vivo without crosslinking and ligation.
Redolfi J, Zhan Y, Valdes-Quezada C, Kryzhanovska M, Guerreiro I, Iesmantavicius V, Pollex T, Grand RS, Mulugeta E, Kind J, Tiana G, Smallwood SA, de Laat W, Giorgetti L. Redolfi J, et al. Among authors: de laat w. Nat Struct Mol Biol. 2019 Jun;26(6):471-480. doi: 10.1038/s41594-019-0231-0. Epub 2019 May 27. Nat Struct Mol Biol. 2019. PMID: 31133702 Free PMC article.
Robust 4C-seq data analysis to screen for regulatory DNA interactions.
van de Werken HJ, Landan G, Holwerda SJ, Hoichman M, Klous P, Chachik R, Splinter E, Valdes-Quezada C, Oz Y, Bouwman BA, Verstegen MJ, de Wit E, Tanay A, de Laat W. van de Werken HJ, et al. Among authors: de laat w, de wit e. Nat Methods. 2012 Oct;9(10):969-72. doi: 10.1038/nmeth.2173. Epub 2012 Sep 9. Nat Methods. 2012. PMID: 22961246
The pluripotent genome in three dimensions is shaped around pluripotency factors.
de Wit E, Bouwman BA, Zhu Y, Klous P, Splinter E, Verstegen MJ, Krijger PH, Festuccia N, Nora EP, Welling M, Heard E, Geijsen N, Poot RA, Chambers I, de Laat W. de Wit E, et al. Among authors: de laat w. Nature. 2013 Sep 12;501(7466):227-31. doi: 10.1038/nature12420. Epub 2013 Jul 24. Nature. 2013. PMID: 23883933
YAP Drives Growth by Controlling Transcriptional Pause Release from Dynamic Enhancers.
Galli GG, Carrara M, Yuan WC, Valdes-Quezada C, Gurung B, Pepe-Mooney B, Zhang T, Geeven G, Gray NS, de Laat W, Calogero RA, Camargo FD. Galli GG, et al. Among authors: de laat w. Mol Cell. 2015 Oct 15;60(2):328-37. doi: 10.1016/j.molcel.2015.09.001. Epub 2015 Oct 1. Mol Cell. 2015. PMID: 26439301 Free PMC article.
CTCF Binding Polarity Determines Chromatin Looping.
de Wit E, Vos ES, Holwerda SJ, Valdes-Quezada C, Verstegen MJ, Teunissen H, Splinter E, Wijchers PJ, Krijger PH, de Laat W. de Wit E, et al. Among authors: de laat w. Mol Cell. 2015 Nov 19;60(4):676-84. doi: 10.1016/j.molcel.2015.09.023. Epub 2015 Oct 29. Mol Cell. 2015. PMID: 26527277 Free article.
Cause and Consequence of Tethering a SubTAD to Different Nuclear Compartments.
Wijchers PJ, Krijger PHL, Geeven G, Zhu Y, Denker A, Verstegen MJAM, Valdes-Quezada C, Vermeulen C, Janssen M, Teunissen H, Anink-Groenen LCM, Verschure PJ, de Laat W. Wijchers PJ, et al. Among authors: de laat w. Mol Cell. 2016 Feb 4;61(3):461-473. doi: 10.1016/j.molcel.2016.01.001. Epub 2016 Jan 28. Mol Cell. 2016. PMID: 26833089 Free PMC article.
140 results