Georg GI - Search Results

1

Revisiting microtubule targeting agents: α-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics.

Coulup SK, Georg GI. Coulup SK, et al. Among authors: georg gi. Bioorg Med Chem Lett. 2019 Aug 1;29(15):1865-1873. doi: 10.1016/j.bmcl.2019.05.042. Epub 2019 May 21. Bioorg Med Chem Lett. 2019. PMID: 31130264 Review.

2

Halohydrin analogues of cryptophycin 1: synthesis and biological activity.

Georg GI, Ali SM, Stella VJ, Waugh WN, Himes RH. Georg GI, et al. Bioorg Med Chem Lett. 1998 Aug 4;8(15):1959-62. doi: 10.1016/s0960-894x(98)00356-4. Bioorg Med Chem Lett. 1998. PMID: 9873466

3

Total synthesis and evaluation of C25-benzyloxyepothilone C for tubulin assembly and cytotoxicity against MCF-7 breast cancer cells.

Hutt OE, Reddy BS, Nair SK, Reiff EA, Henri JT, Greiner JF, Chiu TL, Vandervelde DG, Amin EA, Himes RH, Georg GI. Hutt OE, et al. Among authors: georg gi. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4904-6. doi: 10.1016/j.bmcl.2008.07.024. Epub 2008 Jul 11. Bioorg Med Chem Lett. 2008. PMID: 18684624 Free PMC article.

4

Synthesis, tubulin assembly, and antiproliferative activity against MCF7 and NCI/ADR-RES cancer cells of 10-O-acetyl-5'-hydroxybutitaxel.

Ge H, Wang J, Kayser MM, Himes RH, Georg GI. Ge H, et al. Among authors: georg gi. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6165-7. doi: 10.1016/j.bmcl.2008.10.010. Epub 2008 Oct 7. Bioorg Med Chem Lett. 2008. PMID: 18977659 Free PMC article.

5

Total synthesis and evaluation of 22-(3-azidobenzoyloxy)methyl epothilone C for photoaffinity labeling of beta-tubulin.

Hutt OE, Inagaki J, Reddy BS, Nair SK, Reiff EA, Henri JT, Greiner JF, VanderVelde DG, Chiu TL, Amin EA, Himes RH, Georg GI. Hutt OE, et al. Among authors: georg gi. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3293-6. doi: 10.1016/j.bmcl.2009.04.077. Epub 2009 Apr 22. Bioorg Med Chem Lett. 2009. PMID: 19428248 Free PMC article.

6

Synthesis and evaluation of the anti-proliferative and NF-κB activities of a library of simplified tylophorine analogs.

Niphakis MJ, Gay BC, Hong KH, Bleeker NP, Georg GI. Niphakis MJ, et al. Among authors: georg gi. Bioorg Med Chem. 2012 Oct 1;20(19):5893-900. doi: 10.1016/j.bmc.2012.07.044. Epub 2012 Aug 3. Bioorg Med Chem. 2012. PMID: 22910225

7

Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon Adenocarcinoma and Ovarian Cancer Xenografts.

Patil S, Lis LG, Schumacher RJ, Norris BJ, Morgan ML, Cuellar RA, Blazar BR, Suryanarayanan R, Gurvich VJ, Georg GI. Patil S, et al. Among authors: georg gi. J Med Chem. 2015 Dec 10;58(23):9334-44. doi: 10.1021/acs.jmedchem.5b01329. Epub 2015 Nov 24. J Med Chem. 2015. PMID: 26596892 Free PMC article.

8

Characterizing the Epothilone Binding Site on β-Tubulin by Photoaffinity Labeling: Identification of β-Tubulin Peptides TARGSQQY and TSRGSQQY as Targets of an Epothilone Photoprobe for Polymerized Tubulin.

Ranade AR, Higgins L, Markowski TW, Glaser N, Kashin D, Bai R, Hong KH, Hamel E, Höfle G, Georg GI. Ranade AR, et al. Among authors: georg gi. J Med Chem. 2016 Apr 14;59(7):3499-514. doi: 10.1021/acs.jmedchem.6b00188. Epub 2016 Mar 17. J Med Chem. 2016. PMID: 26986898 Free PMC article.

9

Inducing Protein Degradation as a Therapeutic Strategy.

Crews CM, Georg G, Wang S. Crews CM, et al. J Med Chem. 2016 Jun 9;59(11):5129-30. doi: 10.1021/acs.jmedchem.6b00735. Epub 2016 May 20. J Med Chem. 2016. PMID: 27199030 No abstract available.

10

Synthesis and Cytotoxicity Evaluation of C4- and C5-Modified Analogues of the α,β-Unsaturated Lactone of Pironetin.

Huang DS, Wong HL, Georg GI. Huang DS, et al. Among authors: georg gi. ChemMedChem. 2017 Apr 6;12(7):520-528. doi: 10.1002/cmdc.201700084. Epub 2017 Mar 22. ChemMedChem. 2017. PMID: 28261964 Free PMC article.

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