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Phagocytosis-shielded lentiviral vectors improve liver gene therapy in nonhuman primates.
Milani M, Annoni A, Moalli F, Liu T, Cesana D, Calabria A, Bartolaccini S, Biffi M, Russo F, Visigalli I, Raimondi A, Patarroyo-White S, Drager D, Cristofori P, Ayuso E, Montini E, Peters R, Iannacone M, Cantore A, Naldini L. Milani M, et al. Among authors: cristofori p. Sci Transl Med. 2019 May 22;11(493):eaav7325. doi: 10.1126/scitranslmed.aav7325. Sci Transl Med. 2019. PMID: 31118293 Free PMC article.
Hematopoietic Tumors in a Mouse Model of X-linked Chronic Granulomatous Disease after Lentiviral Vector-Mediated Gene Therapy.
Jofra Hernández R, Calabria A, Sanvito F, De Mattia F, Farinelli G, Scala S, Visigalli I, Carriglio N, De Simone M, Vezzoli M, Cecere F, Migliavacca M, Basso-Ricci L, Omrani M, Benedicenti F, Norata R, Rancoita PMV, Di Serio C, Albertini P, Cristofori P, Naldini L, Gentner B, Montini E, Aiuti A, Mortellaro A. Jofra Hernández R, et al. Among authors: cristofori p. Mol Ther. 2021 Jan 6;29(1):86-102. doi: 10.1016/j.ymthe.2020.09.030. Epub 2020 Sep 23. Mol Ther. 2021. PMID: 33010230 Free PMC article.
Preclinical Testing of the Safety and Tolerability of Lentiviral Vector-Mediated Above-Normal Alpha-L-Iduronidase Expression in Murine and Human Hematopoietic Cells Using Toxicology and Biodistribution Good Laboratory Practice Studies.
Visigalli I, Delai S, Ferro F, Cecere F, Vezzoli M, Sanvito F, Chanut F, Benedicenti F, Spinozzi G, Wynn R, Calabria A, Naldini L, Montini E, Cristofori P, Biffi A. Visigalli I, et al. Among authors: cristofori p. Hum Gene Ther. 2016 Oct;27(10):813-829. doi: 10.1089/hum.2016.068. Hum Gene Ther. 2016. PMID: 27431943
Multiple Integrated Non-clinical Studies Predict the Safety of Lentivirus-Mediated Gene Therapy for β-Thalassemia.
Lidonnici MR, Paleari Y, Tiboni F, Mandelli G, Rossi C, Vezzoli M, Aprile A, Lederer CW, Ambrosi A, Chanut F, Sanvito F, Calabria A, Poletti V, Mavilio F, Montini E, Naldini L, Cristofori P, Ferrari G. Lidonnici MR, et al. Among authors: cristofori p. Mol Ther Methods Clin Dev. 2018 Sep 13;11:9-28. doi: 10.1016/j.omtm.2018.09.001. eCollection 2018 Dec 14. Mol Ther Methods Clin Dev. 2018. PMID: 30320151 Free PMC article.
Good Laboratory Practice Preclinical Safety Studies for GSK2696273 (MLV Vector-Based Ex Vivo Gene Therapy for Adenosine Deaminase Deficiency Severe Combined Immunodeficiency) in NSG Mice.
Carriglio N, Klapwijk J, Hernandez RJ, Vezzoli M, Chanut F, Lowe R, Draghici E, Nord M, Albertini P, Cristofori P, Richards J, Staton H, Appleby J, Aiuti A, Sauer AV. Carriglio N, et al. Among authors: cristofori p. Hum Gene Ther Clin Dev. 2017 Mar;28(1):17-27. doi: 10.1089/humc.2016.191. Hum Gene Ther Clin Dev. 2017. PMID: 28319446
Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells.
Norelli M, Camisa B, Barbiera G, Falcone L, Purevdorj A, Genua M, Sanvito F, Ponzoni M, Doglioni C, Cristofori P, Traversari C, Bordignon C, Ciceri F, Ostuni R, Bonini C, Casucci M, Bondanza A. Norelli M, et al. Among authors: cristofori p. Nat Med. 2018 Jun;24(6):739-748. doi: 10.1038/s41591-018-0036-4. Epub 2018 May 28. Nat Med. 2018. PMID: 29808007
Spontaneous cardiomyopathy in young Sprague-Dawley rats: evaluation of biological and environmental variability.
Chanut F, Kimbrough C, Hailey R, Berridge B, Hughes-Earle A, Davies R, Roland K, Stokes A, Casartelli A, York M, Jordan H, Crivellente F, Cristofori P, Thomas H, Klapwijk J, Adler R. Chanut F, et al. Among authors: cristofori p. Toxicol Pathol. 2013;41(8):1126-36. doi: 10.1177/0192623313478692. Epub 2013 Mar 7. Toxicol Pathol. 2013. PMID: 23475560
55 results