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Antileukemic activity and mechanism of action of the novel PI3K and histone deacetylase dual inhibitor CUDC-907 in acute myeloid leukemia.
Li X, Su Y, Madlambayan G, Edwards H, Polin L, Kushner J, Dzinic SH, White K, Ma J, Knight T, Wang G, Wang Y, Yang J, Taub JW, Lin H, Ge Y. Li X, et al. Among authors: wang g, wang y. Haematologica. 2019 Nov;104(11):2225-2240. doi: 10.3324/haematol.2018.201343. Epub 2019 Feb 28. Haematologica. 2019. PMID: 30819918 Free PMC article.
Inhibition of Bcl-2 Synergistically Enhances the Antileukemic Activity of Midostaurin and Gilteritinib in Preclinical Models of FLT3-Mutated Acute Myeloid Leukemia.
Ma J, Zhao S, Qiao X, Knight T, Edwards H, Polin L, Kushner J, Dzinic SH, White K, Wang G, Zhao L, Lin H, Wang Y, Taub JW, Ge Y. Ma J, et al. Among authors: wang g, wang y. Clin Cancer Res. 2019 Nov 15;25(22):6815-6826. doi: 10.1158/1078-0432.CCR-19-0832. Epub 2019 Jul 18. Clin Cancer Res. 2019. PMID: 31320594 Free PMC article.
Simultaneous cotargeting of ATR and RNA Polymerase I transcription demonstrates synergistic antileukemic effects on acute myeloid leukemia.
Wang T, Shatara M, Liu F, Knight T, Edwards H, Wang G, Lin H, Wang Y, Taub JW, Ge Y. Wang T, et al. Among authors: wang g, wang y. Signal Transduct Target Ther. 2019 Nov 1;4:44. doi: 10.1038/s41392-019-0076-3. eCollection 2019. Signal Transduct Target Ther. 2019. PMID: 31700693 Free PMC article. No abstract available.
The HDAC and PI3K dual inhibitor CUDC-907 synergistically enhances the antileukemic activity of venetoclax in preclinical models of acute myeloid leukemia.
Li X, Su Y, Hege K, Madlambayan G, Edwards H, Knight T, Polin L, Kushner J, Dzinic SH, White K, Yang J, Miller R, Wang G, Zhao L, Wang Y, Lin H, Taub JW, Ge Y. Li X, et al. Among authors: wang g, wang y. Haematologica. 2021 May 1;106(5):1262-1277. doi: 10.3324/haematol.2019.233445. Haematologica. 2021. PMID: 32165486 Free PMC article.
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