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ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes.
Fang C, Manes TD, Liu L, Liu K, Qin L, Li G, Tobiasova Z, Kirkiles-Smith NC, Patel M, Merola J, Fu W, Liu R, Xie C, Tietjen GT, Nigrovic PA, Tellides G, Pober JS, Jane-Wit D. Fang C, et al. Among authors: manes td. Nat Commun. 2019 May 21;10(1):2247. doi: 10.1038/s41467-019-10041-2. Nat Commun. 2019. PMID: 31113953 Free PMC article.
Alloantibody and complement promote T cell-mediated cardiac allograft vasculopathy through noncanonical nuclear factor-κB signaling in endothelial cells.
Jane-Wit D, Manes TD, Yi T, Qin L, Clark P, Kirkiles-Smith NC, Abrahimi P, Devalliere J, Moeckel G, Kulkarni S, Tellides G, Pober JS. Jane-Wit D, et al. Among authors: manes td. Circulation. 2013 Dec 3;128(23):2504-16. doi: 10.1161/CIRCULATIONAHA.113.002972. Epub 2013 Sep 17. Circulation. 2013. PMID: 24045046 Free PMC article.
Complement membrane attack complexes activate noncanonical NF-κB by forming an Akt+ NIK+ signalosome on Rab5+ endosomes.
Jane-wit D, Surovtseva YV, Qin L, Li G, Liu R, Clark P, Manes TD, Wang C, Kashgarian M, Kirkiles-Smith NC, Tellides G, Pober JS. Jane-wit D, et al. Among authors: manes td. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9686-91. doi: 10.1073/pnas.1503535112. Epub 2015 Jul 20. Proc Natl Acad Sci U S A. 2015. PMID: 26195760 Free PMC article.
Antigen Presentation by Vascular Cells.
Pober JS, Merola J, Liu R, Manes TD. Pober JS, et al. Among authors: manes td. Front Immunol. 2017 Dec 22;8:1907. doi: 10.3389/fimmu.2017.01907. eCollection 2017. Front Immunol. 2017. PMID: 29312357 Free PMC article. Review.
44 results