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SR Ca2+-leak and disordered excitation-contraction coupling as the basis for arrhythmogenic and negative inotropic effects of acute ethanol exposure.
Mustroph J, Wagemann O, Lebek S, Tarnowski D, Ackermann J, Drzymalski M, Pabel S, Schmid C, Wagner S, Sossalla S, Maier LS, Neef S. Mustroph J, et al. Among authors: lebek s. J Mol Cell Cardiol. 2018 Mar;116:81-90. doi: 10.1016/j.yjmcc.2018.02.002. Epub 2018 Feb 3. J Mol Cell Cardiol. 2018. PMID: 29410242 Free article.
The novel CaMKII inhibitor GS-680 reduces diastolic SR Ca leak and prevents CaMKII-dependent pro-arrhythmic activity.
Lebek S, Plößl A, Baier M, Mustroph J, Tarnowski D, Lücht CM, Schopka S, Flörchinger B, Schmid C, Zausig Y, Pagratis N, Marchand B, Koltun DO, Hung WK, Ahmadyar S, Belardinelli L, Maier LS, Wagner S. Lebek S, et al. J Mol Cell Cardiol. 2018 May;118:159-168. doi: 10.1016/j.yjmcc.2018.03.020. Epub 2018 Mar 31. J Mol Cell Cardiol. 2018. PMID: 29614261
Empagliflozin reduces Ca/calmodulin-dependent kinase II activity in isolated ventricular cardiomyocytes.
Mustroph J, Wagemann O, Lücht CM, Trum M, Hammer KP, Sag CM, Lebek S, Tarnowski D, Reinders J, Perbellini F, Terracciano C, Schmid C, Schopka S, Hilker M, Zausig Y, Pabel S, Sossalla ST, Schweda F, Maier LS, Wagner S. Mustroph J, et al. Among authors: lebek s. ESC Heart Fail. 2018 Aug;5(4):642-648. doi: 10.1002/ehf2.12336. ESC Heart Fail. 2018. PMID: 30117720 Free PMC article.
Dantrolene reduces CaMKIIδC-mediated atrial arrhythmias.
Pabel S, Mustroph J, Stehle T, Lebek S, Dybkova N, Keyser A, Rupprecht L, Wagner S, Neef S, Maier LS, Sossalla S. Pabel S, et al. Among authors: lebek s. Europace. 2020 Jul 1;22(7):1111-1118. doi: 10.1093/europace/euaa079. Europace. 2020. PMID: 32413138
Angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker treatment and haemodynamic factors are associated with increased cardiac mRNA expression of angiotensin-converting enzyme 2 in patients with cardiovascular disease.
Lebek S, Tafelmeier M, Messmann R, Provaznik Z, Schmid C, Maier LS, Birner C, Arzt M, Wagner S. Lebek S, et al. Eur J Heart Fail. 2020 Dec;22(12):2248-2257. doi: 10.1002/ejhf.2020. Epub 2020 Oct 20. Eur J Heart Fail. 2020. PMID: 33017071 Free PMC article.
60 results