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Page 1
A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo.
Xie SC, Tai CW, Morton CJ, Ma L, Huang SC, Wittlin S, Du Y, Hu Y, Dogovski C, Salimimarand M, Griffin R, England D, de la Cruz E, Deni I, Yeo T, Burkhard AY, Striepen J, Schindler KA, Crespo B, Gamo FJ, Khandokar Y, Hutton CA, Rabie T, Birkholtz LM, Famodimu MT, Delves MJ, Bolsher J, Koolen KMJ, van der Laak R, Aguiar ACC, Pereira DB, Guido RVC, Creek DJ, Fidock DA, Dick LR, Brand SL, Gould AE, Langston S, Griffin MDW, Tilley L. Xie SC, et al. Among authors: burkhard ay. PLoS Pathog. 2024 Dec 9;20(12):e1012429. doi: 10.1371/journal.ppat.1012429. eCollection 2024 Dec. PLoS Pathog. 2024. PMID: 39652589 Free PMC article.
Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission.
Gomez-Gonzalez PJ, Gupta A, Drought LG, Patel A, Okombo J, van der Watt M, Walker-Gray R, Schindler KA, Burkhard AY, Yeo T, Narwal SK, Bloxham TS, Flueck C, Walker EM, Rey JA, Fairhurst KJ, Reader J, Park H, Pollard HG, Stewart LB, Brandner-Garrod L, Kristan M, Sterk GJ, van Nuland YM, Manko E, van Schalkwyk DA, Zheng Y, Leurs R, Dechering KJ, Aguiar ACC, Guido RVC, Pereira DB, Tumwebaze PK, Nosbya SL, Rosenthal PJ, Cooper RA, Palmer M, Parkinson T, Burrows JN, Uhlemann AC, Birkholtz LM, Small-Saunders JL, Duffy J, Fidock DA, Brown A, Gardner M, Baker DA. Gomez-Gonzalez PJ, et al. Among authors: burkhard ay. Sci Adv. 2024 Dec 6;10(49):eadq1383. doi: 10.1126/sciadv.adq1383. Epub 2024 Dec 6. Sci Adv. 2024. PMID: 39642214 Free PMC article.
Artemisinin resistance mutations in Pfcoronin impede hemoglobin uptake.
Ullah I, Farringer MA, Burkhard AY, Hathaway E, Khushu M, Willett BC, Shin SH, Sharma AI, Martin MC, Shao KL, Dvorin JD, Hartl DL, Volkman SK, Bopp S, Absalon S, Wirth DF. Ullah I, et al. Among authors: burkhard ay. bioRxiv [Preprint]. 2024 May 30:2023.12.22.572193. doi: 10.1101/2023.12.22.572193. bioRxiv. 2024. PMID: 38187525 Free PMC article. Preprint.
Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness.
Mok S, Yeo T, Hong D, Shears MJ, Ross LS, Ward KE, Dhingra SK, Kanai M, Bridgford JL, Tripathi AK, Mlambo G, Burkhard AY, Ansbro MR, Fairhurst KJ, Gil-Iturbe E, Park H, Rozenberg FD, Kim J, Mancia F, Fairhurst RM, Quick M, Uhlemann AC, Sinnis P, Fidock DA. Mok S, et al. Among authors: burkhard ay. Sci Adv. 2023 Nov 10;9(45):eadi2364. doi: 10.1126/sciadv.adi2364. Epub 2023 Nov 8. Sci Adv. 2023. PMID: 37939186 Free PMC article.
Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness.
Mok S, Yeo T, Hong D, Shears MJ, Ross LS, Ward KE, Dhingra SK, Kanai M, Bridgford JL, Tripathi AK, Mlambo G, Burkhard AY, Fairhurst KJ, Gil-Iturbe E, Park H, Rozenberg FD, Kim J, Mancia F, Quick M, Uhlemann AC, Sinnis P, Fidock DA. Mok S, et al. Among authors: burkhard ay. bioRxiv [Preprint]. 2023 Jun 3:2023.06.02.543338. doi: 10.1101/2023.06.02.543338. bioRxiv. 2023. Update in: Sci Adv. 2023 Nov 10;9(45):eadi2364. doi: 10.1126/sciadv.adi2364. PMID: 37398288 Free PMC article. Updated. Preprint.
Phenotyping of the thoracic-onset variant of amyotrophic lateral sclerosis.
Kandler K, Witzel S, Eder K, Rothenbacher D, Nagel G, Peter RS, Schuster J, Dorst J, Rosenbohm A, Ludolph AC; ALS Registry Study Group. Kandler K, et al. J Neurol Neurosurg Psychiatry. 2022 May;93(5):563-565. doi: 10.1136/jnnp-2021-326712. Epub 2021 Oct 19. J Neurol Neurosurg Psychiatry. 2022. PMID: 34667101 No abstract available.
The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance.
Murithi JM, Deni I, Pasaje CFA, Okombo J, Bridgford JL, Gnädig NF, Edwards RL, Yeo T, Mok S, Burkhard AY, Coburn-Flynn O, Istvan ES, Sakata-Kato T, Gomez-Lorenzo MG, Cowell AN, Wicht KJ, Le Manach C, Kalantarov GF, Dey S, Duffey M, Laleu B, Lukens AK, Ottilie S, Vanaerschot M, Trakht IN, Gamo FJ, Wirth DF, Goldberg DE, Odom John AR, Chibale K, Winzeler EA, Niles JC, Fidock DA. Murithi JM, et al. Among authors: burkhard ay. Cell Chem Biol. 2022 May 19;29(5):824-839.e6. doi: 10.1016/j.chembiol.2021.06.006. Epub 2021 Jul 6. Cell Chem Biol. 2022. PMID: 34233174 Free PMC article.
33 results