Sit R - Search Results

1

Assessment of ionizable, zwitterionic oximes as reactivating antidotal agents for organophosphate exposure.

Taylor P, Yan-Jye S, Momper J, Hou W, Camacho-Hernandez GA, Radic' Z, Rosenberg Y, Kovarik Z, Sit R, Sharpless KB. Taylor P, et al. Among authors: sit r. Chem Biol Interact. 2019 Aug 1;308:194-197. doi: 10.1016/j.cbi.2019.05.015. Epub 2019 May 14. Chem Biol Interact. 2019. PMID: 31100277 Review.

2

New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases.

Sit RK, Radić Z, Gerardi V, Zhang L, Garcia E, Katalinić M, Amitai G, Kovarik Z, Fokin VV, Sharpless KB, Taylor P. Sit RK, et al. J Biol Chem. 2011 Jun 3;286(22):19422-30. doi: 10.1074/jbc.M111.230656. Epub 2011 Apr 4. J Biol Chem. 2011. PMID: 21464125 Free PMC article.

3

Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases.

Radić Z, Sit RK, Kovarik Z, Berend S, Garcia E, Zhang L, Amitai G, Green C, Radić B, Fokin VV, Sharpless KB, Taylor P. Radić Z, et al. J Biol Chem. 2012 Apr 6;287(15):11798-809. doi: 10.1074/jbc.M111.333732. Epub 2012 Feb 16. J Biol Chem. 2012. PMID: 22343626 Free PMC article.

4

Centrally acting oximes in reactivation of tabun-phosphoramidated AChE.

Kovarik Z, Maček N, Sit RK, Radić Z, Fokin VV, Barry Sharpless K, Taylor P. Kovarik Z, et al. Chem Biol Interact. 2013 Mar 25;203(1):77-80. doi: 10.1016/j.cbi.2012.08.019. Epub 2012 Sep 7. Chem Biol Interact. 2013. PMID: 22960624 Free PMC article.

5

Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates.

Radić Z, Sit RK, Garcia E, Zhang L, Berend S, Kovarik Z, Amitai G, Fokin VV, Barry Sharpless K, Taylor P. Radić Z, et al. Chem Biol Interact. 2013 Mar 25;203(1):67-71. doi: 10.1016/j.cbi.2012.08.014. Epub 2012 Sep 4. Chem Biol Interact. 2013. PMID: 22975155 Free PMC article.

6

Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification.

Sit RK, Fokin VV, Amitai G, Sharpless KB, Taylor P, Radić Z. Sit RK, et al. J Med Chem. 2014 Feb 27;57(4):1378-89. doi: 10.1021/jm401650z. Epub 2014 Feb 7. J Med Chem. 2014. PMID: 24571195 Free PMC article.

7

Pharmacology, Pharmacokinetics, and Tissue Disposition of Zwitterionic Hydroxyiminoacetamido Alkylamines as Reactivating Antidotes for Organophosphate Exposure.

Sit RK, Kovarik Z, Maček Hrvat N, Žunec S, Green C, Fokin VV, Sharpless KB, Radić Z, Taylor P. Sit RK, et al. J Pharmacol Exp Ther. 2018 Nov;367(2):363-372. doi: 10.1124/jpet.118.249383. Epub 2018 Sep 6. J Pharmacol Exp Ther. 2018. PMID: 30190337 Free PMC article.

8

Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase.

Kovarik Z, Maček Hrvat N, Kalisiak J, Katalinić M, Sit RK, Zorbaz T, Radić Z, Fokin VV, Sharpless KB, Taylor P. Kovarik Z, et al. Toxicol Appl Pharmacol. 2019 Jun 1;372:40-46. doi: 10.1016/j.taap.2019.04.007. Epub 2019 Apr 9. Toxicol Appl Pharmacol. 2019. PMID: 30978400

9

Enhancing Target Tissue Levels and Diminishing Plasma Clearance of Ionizing Zwitterionic Antidotes in Organophosphate Exposures.

Shyong YJ, Sepulveda Y, Garcia A, Samskey NM, Radic Z, Sit RK, Sharpless KB, Momper JD, Taylor P. Shyong YJ, et al. J Pharmacol Exp Ther. 2021 Sep;378(3):315-321. doi: 10.1124/jpet.121.000715. Epub 2021 Jun 18. J Pharmacol Exp Ther. 2021. PMID: 34145064 Free PMC article.

10

Catalytic Soman Scavenging by the Y337A/F338A Acetylcholinesterase Mutant Assisted with Novel Site-Directed Aldoximes.

Kovarik Z, Maček Hrvat N, Katalinić M, Sit RK, Paradyse A, Žunec S, Musilek K, Fokin VV, Taylor P, Radić Z. Kovarik Z, et al. Chem Res Toxicol. 2015 May 18;28(5):1036-44. doi: 10.1021/acs.chemrestox.5b00060. Epub 2015 Apr 16. Chem Res Toxicol. 2015. PMID: 25835984 Free PMC article.

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