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Page 1
Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition.
Esler WP, Tesz GJ, Hellerstein MK, Beysen C, Sivamani R, Turner SM, Watkins SM, Amor PA, Carvajal-Gonzalez S, Geoly FJ, Biddle KE, Purkal JJ, Fitch M, Buckeridge C, Silvia AM, Griffith DA, Gorgoglione M, Hassoun L, Bosanac SS, Vera NB, Rolph TP, Pfefferkorn JA, Sonnenberg GE. Esler WP, et al. Among authors: biddle ke. Sci Transl Med. 2019 May 15;11(492):eaau8465. doi: 10.1126/scitranslmed.aau8465. Sci Transl Med. 2019. PMID: 31092695 Clinical Trial.
A Diagnostic Approach for Rodent Progressive Cardiomyopathy and Like Lesions in Toxicology Studies up to 28 Days in the Sprague Dawley Rat (Part 1 of 2).
Hailey JR, Maleeff BE, Thomas HC, Pearse G, Klapwijk JC, Cristofori PG, Berridge B, Kimbrough CL, Parker GA, Morton D, Elmore S, Hardisty JF, Dybdal NO, Rehagen DA, Fikes JD, Lamb M, Biddle K, Buetow BS, Carreira V, Nyska A, Tripathi NK, Workman HC, Bienvenu JG, Brees I, Turk JR, Adler RR. Hailey JR, et al. Toxicol Pathol. 2017 Dec;45(8):1043-1054. doi: 10.1177/0192623317743938. Epub 2017 Nov 26. Toxicol Pathol. 2017. PMID: 29173114
A Diagnostic Approach for Rodent Progressive Cardiomyopathy and Like Lesions in Toxicology Studies up to 28 Days in the Sprague Dawley Rat (Part 2 of 2).
Hailey JR, Maleeff BE, Thomas HC, Pearse G, Klapwijk JC, Cristofori PG, Berridge B, Kimbrough CL, Parker GA, Morton D, Elmore S, Hardisty JF, Dybdal NO, Rehagen DA, Fikes JD, Lamb M, Biddle K, Buetow BS, Carreira V, Nyska A, Tripathi NK, Workman HC, Bienvenu JG, Brees I, Turk JR, Adler RR. Hailey JR, et al. Toxicol Pathol. 2017 Dec;45(8):1055-1066. doi: 10.1177/0192623317743948. Toxicol Pathol. 2017. PMID: 29233079
Use of the dTAG system in vivo to degrade CDK2 and CDK5 in adult mice and explore potential safety liabilities.
Yenerall P, Sung T, Palyada K, Qian J, Arat S, Kumpf SW, Wang SW, Biddle K, Esparza C, Chang S, Scott W, Collette W, Winrow TS, Affolter T, Shirai N, Thibault S, Wang J, Liu L, Bauchmann M, Frey J, Steyn S, Sacaan A, Vitsky A, Ahn Y, Paul T, Lum L, Oyer J, Yang A, Hu W. Yenerall P, et al. Toxicol Sci. 2023 Jun 28;194(1):53-69. doi: 10.1093/toxsci/kfad049. Toxicol Sci. 2023. PMID: 37228089 Free PMC article.
Liver Microvascular Injury and Thrombocytopenia of Antibody-Calicheamicin Conjugates in Cynomolgus Monkeys-Mechanism and Monitoring.
Guffroy M, Falahatpisheh H, Biddle K, Kreeger J, Obert L, Walters K, Goldstein R, Boucher G, Coskran T, Reagan W, Sullivan D, Huang C, Sokolowski S, Giovanelli R, Gerber HP, Finkelstein M, Khan N. Guffroy M, et al. Clin Cancer Res. 2017 Apr 1;23(7):1760-1770. doi: 10.1158/1078-0432.CCR-16-0939. Epub 2016 Sep 28. Clin Cancer Res. 2017. PMID: 27683177
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