Bell AS - Search Results

1

Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors.

Schlott AC, Mayclin S, Reers AR, Coburn-Flynn O, Bell AS, Green J, Knuepfer E, Charter D, Bonnert R, Campo B, Burrows J, Lyons-Abbott S, Staker BL, Chung CW, Myler PJ, Fidock DA, Tate EW, Holder AA. Schlott AC, et al. Among authors: bell as. Cell Chem Biol. 2019 Jul 18;26(7):991-1000.e7. doi: 10.1016/j.chembiol.2019.03.015. Epub 2019 May 9. Cell Chem Biol. 2019. PMID: 31080074 Free PMC article.

2

Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs.

Bell AS, Mills JE, Williams GP, Brannigan JA, Wilkinson AJ, Parkinson T, Leatherbarrow RJ, Tate EW, Holder AA, Smith DF. Bell AS, et al. PLoS Negl Trop Dis. 2012;6(4):e1625. doi: 10.1371/journal.pntd.0001625. Epub 2012 Apr 24. PLoS Negl Trop Dis. 2012. PMID: 22545171 Free PMC article.

3

N-Myristoyltransferase as a potential drug target in malaria and leishmaniasis.

Tate EW, Bell AS, Rackham MD, Wright MH. Tate EW, et al. Among authors: bell as. Parasitology. 2014 Jan;141(1):37-49. doi: 10.1017/S0031182013000450. Epub 2013 Apr 24. Parasitology. 2014. PMID: 23611109 Free article. Review.

4

Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors.

Brannigan JA, Roberts SM, Bell AS, Hutton JA, Hodgkinson MR, Tate EW, Leatherbarrow RJ, Smith DF, Wilkinson AJ. Brannigan JA, et al. Among authors: bell as. IUCrJ. 2014 Jun 17;1(Pt 4):250-60. doi: 10.1107/S2052252514013001. eCollection 2014 Jul 1. IUCrJ. 2014. PMID: 25075346 Free PMC article.

5

Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors.

Hutton JA, Goncalves V, Brannigan JA, Paape D, Wright MH, Waugh TM, Roberts SM, Bell AS, Wilkinson AJ, Smith DF, Leatherbarrow RJ, Tate EW. Hutton JA, et al. Among authors: bell as. J Med Chem. 2014 Oct 23;57(20):8664-70. doi: 10.1021/jm5011397. Epub 2014 Oct 1. J Med Chem. 2014. PMID: 25238611 Free PMC article.

6

Using a non-image-based medium-throughput assay for screening compounds targeting N-myristoylation in intracellular Leishmania amastigotes.

Paape D, Bell AS, Heal WP, Hutton JA, Leatherbarrow RJ, Tate EW, Smith DF. Paape D, et al. Among authors: bell as. PLoS Negl Trop Dis. 2014 Dec 18;8(12):e3363. doi: 10.1371/journal.pntd.0003363. eCollection 2014 Dec. PLoS Negl Trop Dis. 2014. PMID: 25522361 Free PMC article.

7

Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase.

Goncalves V, Brannigan JA, Laporte A, Bell AS, Roberts SM, Wilkinson AJ, Leatherbarrow RJ, Tate EW. Goncalves V, et al. Among authors: bell as. Medchemcomm. 2017 Jan 1;8(1):191-197. doi: 10.1039/c6md00531d. Epub 2016 Nov 11. Medchemcomm. 2017. PMID: 28626547 Free PMC article.

8

Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus.

Mousnier A, Bell AS, Swieboda DP, Morales-Sanfrutos J, Pérez-Dorado I, Brannigan JA, Newman J, Ritzefeld M, Hutton JA, Guedán A, Asfor AS, Robinson SW, Hopkins-Navratilova I, Wilkinson AJ, Johnston SL, Leatherbarrow RJ, Tuthill TJ, Solari R, Tate EW. Mousnier A, et al. Among authors: bell as. Nat Chem. 2018 Jun;10(6):599-606. doi: 10.1038/s41557-018-0039-2. Epub 2018 May 14. Nat Chem. 2018. PMID: 29760414 Free PMC article.

9

Novel Thienopyrimidine Inhibitors of Leishmania N-Myristoyltransferase with On-Target Activity in Intracellular Amastigotes.

Bell AS, Yu Z, Hutton JA, Wright MH, Brannigan JA, Paape D, Roberts SM, Sutherell CL, Ritzefeld M, Wilkinson AJ, Smith DF, Leatherbarrow RJ, Tate EW. Bell AS, et al. J Med Chem. 2020 Jul 23;63(14):7740-7765. doi: 10.1021/acs.jmedchem.0c00570. Epub 2020 Jul 14. J Med Chem. 2020. PMID: 32575985 Free PMC article.

10

Structure of Plasmodium vivaxN-myristoyltransferase with inhibitor IMP-1088: exploring an NMT inhibitor for antimalarial therapy.

Mendez A, Bolling C, Taylor S, Makumire S, Staker B, Reers A, Hammerson B, Mayclin SJ, Abendroth J, Lorimer DD, Edwards TE, Tate EW, Subramanian S, Bell AS, Myler PJ, Asojo OA, Chakafana G. Mendez A, et al. Among authors: bell as. Acta Crystallogr F Struct Biol Commun. 2025 Jan 1. doi: 10.1107/S2053230X24011348. Online ahead of print. Acta Crystallogr F Struct Biol Commun. 2025. PMID: 39655507

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