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Page 1
Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections.
Bakowski MA, Shiroodi RK, Liu R, Olejniczak J, Yang B, Gagaring K, Guo H, White PM, Chappell L, Debec A, Landmann F, Dubben B, Lenz F, Struever D, Ehrens A, Frohberger SJ, Sjoberg H, Pionnier N, Murphy E, Archer J, Steven A, Chunda VC, Fombad FF, Chounna PW, Njouendou AJ, Metuge HM, Ndzeshang BL, Gandjui NV, Akumtoh DN, Kwenti TDB, Woods AK, Joseph SB, Hull MV, Xiong W, Kuhen KL, Taylor MJ, Wanji S, Turner JD, Hübner MP, Hoerauf A, Chatterjee AK, Roland J, Tremblay MS, Schultz PG, Sullivan W, Chu XJ, Petrassi HM, McNamara CW. Bakowski MA, et al. Among authors: steven a. Sci Transl Med. 2019 May 8;11(491):eaav3523. doi: 10.1126/scitranslmed.aav3523. Sci Transl Med. 2019. PMID: 31068442
Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis.
Sharma R, Al Jayoussi G, Tyrer HE, Gamble J, Hayward L, Guimaraes AF, Davies J, Waterhouse D, Cook DA, Myhill LJ, Clare RH, Cassidy A, Steven A, Johnston KL, Ford L, Turner JD, Ward SA, Taylor MJ. Sharma R, et al. Among authors: steven a. Sci Rep. 2016 Mar 21;6:23458. doi: 10.1038/srep23458. Sci Rep. 2016. PMID: 26996237 Free PMC article.
Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis.
Aljayyoussi G, Tyrer HE, Ford L, Sjoberg H, Pionnier N, Waterhouse D, Davies J, Gamble J, Metuge H, Cook DAN, Steven A, Sharma R, Guimaraes AF, Clare RH, Cassidy A, Johnston KL, Myhill L, Hayward L, Wanji S, Turner JD, Taylor MJ, Ward SA. Aljayyoussi G, et al. Among authors: steven a. Sci Rep. 2017 Mar 16;7(1):210. doi: 10.1038/s41598-017-00322-5. Sci Rep. 2017. PMID: 28303006 Free PMC article.
Albendazole and antibiotics synergize to deliver short-course anti-Wolbachia curative treatments in preclinical models of filariasis.
Turner JD, Sharma R, Al Jayoussi G, Tyrer HE, Gamble J, Hayward L, Priestley RS, Murphy EA, Davies J, Waterhouse D, Cook DAN, Clare RH, Cassidy A, Steven A, Johnston KL, McCall J, Ford L, Hemingway J, Ward SA, Taylor MJ. Turner JD, et al. Among authors: steven a. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9712-E9721. doi: 10.1073/pnas.1710845114. Epub 2017 Oct 23. Proc Natl Acad Sci U S A. 2017. PMID: 29078351 Free PMC article.
Author Correction: Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis.
Aljayyoussi G, Tyrer HE, Ford L, Sjoberg H, Pionnier N, Waterhouse D, Davies J, Gamble J, Metuge H, Cook DAN, Steven A, Sharma R, Guimaraes AF, Clare RH, Cassidy A, Johnston KL, Myhill L, Hayward L, Wanji S, Turner JD, Taylor MJ, Ward SA. Aljayyoussi G, et al. Among authors: steven a. Sci Rep. 2018 Jan 18;8(1):1384. doi: 10.1038/s41598-018-19723-1. Sci Rep. 2018. PMID: 29348597 Free PMC article.
Interleukin-4 activated macrophages mediate immunity to filarial helminth infection by sustaining CCR3-dependent eosinophilia.
Turner JD, Pionnier N, Furlong-Silva J, Sjoberg H, Cross S, Halliday A, Guimaraes AF, Cook DAN, Steven A, Van Rooijen N, Allen JE, Jenkins SJ, Taylor MJ. Turner JD, et al. Among authors: steven a. PLoS Pathog. 2018 Mar 16;14(3):e1006949. doi: 10.1371/journal.ppat.1006949. eCollection 2018 Mar. PLoS Pathog. 2018. PMID: 29547639 Free PMC article.
Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides.
Clare RH, Bardelle C, Harper P, Hong WD, Börjesson U, Johnston KL, Collier M, Myhill L, Cassidy A, Plant D, Plant H, Clark R, Cook DAN, Steven A, Archer J, McGillan P, Charoensutthivarakul S, Bibby J, Sharma R, Nixon GL, Slatko BE, Cantin L, Wu B, Turner J, Ford L, Rich K, Wigglesworth M, Berry NG, O'Neill PM, Taylor MJ, Ward SA. Clare RH, et al. Among authors: steven a. Nat Commun. 2019 Jan 2;10(1):11. doi: 10.1038/s41467-018-07826-2. Nat Commun. 2019. PMID: 30602718 Free PMC article.
492 results