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Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response.
Baeuerle PA, Ding J, Patel E, Thorausch N, Horton H, Gierut J, Scarfo I, Choudhary R, Kiner O, Krishnamurthy J, Le B, Morath A, Baldeviano GC, Quinn J, Tavares P, Wei Q, Weiler S, Maus MV, Getts D, Schamel WW, Hofmeister R. Baeuerle PA, et al. Among authors: thorausch n. Nat Commun. 2019 May 7;10(1):2087. doi: 10.1038/s41467-019-10097-0. Nat Commun. 2019. PMID: 31064990 Free PMC article.
PSMA-Directed CAR T Cells Combined with Low-Dose Docetaxel Treatment Induce Tumor Regression in a Prostate Cancer Xenograft Model.
Alzubi J, Dettmer-Monaco V, Kuehle J, Thorausch N, Seidl M, Taromi S, Schamel W, Zeiser R, Abken H, Cathomen T, Wolf P. Alzubi J, et al. Among authors: thorausch n. Mol Ther Oncolytics. 2020 Jun 24;18:226-235. doi: 10.1016/j.omto.2020.06.014. eCollection 2020 Sep 25. Mol Ther Oncolytics. 2020. PMID: 32728611 Free PMC article.
Molecular mechanism of SHP2 activation by PD-1 stimulation.
Marasco M, Berteotti A, Weyershaeuser J, Thorausch N, Sikorska J, Krausze J, Brandt HJ, Kirkpatrick J, Rios P, Schamel WW, Köhn M, Carlomagno T. Marasco M, et al. Among authors: thorausch n. Sci Adv. 2020 Jan 31;6(5):eaay4458. doi: 10.1126/sciadv.aay4458. eCollection 2020 Jan. Sci Adv. 2020. PMID: 32064351 Free PMC article.