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Structure and function of a malaria transmission blocking vaccine targeting Pfs230 and Pfs230-Pfs48/45 proteins.
Singh K, Burkhardt M, Nakuchima S, Herrera R, Muratova O, Gittis AG, Kelnhofer E, Reiter K, Smelkinson M, Veltri D, Swihart BJ, Shimp R Jr, Nguyen V, Zhang B, MacDonald NJ, Duffy PE, Garboczi DN, Narum DL. Singh K, et al. Among authors: swihart bj. Commun Biol. 2020 Jul 24;3(1):395. doi: 10.1038/s42003-020-01123-9. Commun Biol. 2020. PMID: 32709983 Free PMC article.
Pfs230 yields higher malaria transmission-blocking vaccine activity than Pfs25 in humans but not mice.
Healy SA, Anderson C, Swihart BJ, Mwakingwe A, Gabriel EE, Decederfelt H, Hobbs CV, Rausch KM, Zhu D, Muratova O, Herrera R, Scaria PV, MacDonald NJ, Lambert LE, Zaidi I, Coelho CH, Renn JP, Wu Y, Narum DL, Duffy PE. Healy SA, et al. Among authors: swihart bj. J Clin Invest. 2021 Apr 1;131(7):e146221. doi: 10.1172/JCI146221. J Clin Invest. 2021. PMID: 33561016 Free PMC article. Clinical Trial.
Antibody levels to recombinant VAR2CSA domains vary with Plasmodium falciparum parasitaemia, gestational age, and gravidity, but do not predict pregnancy outcomes.
Fried M, Kurtis JD, Swihart B, Morrison R, Pond-Tor S, Barry A, Sidibe Y, Keita S, Mahamar A, Andemel N, Attaher O, Dembele AB, Cisse KB, Diarra BS, Kanoute MB, Narum DL, Dicko A, Duffy PE. Fried M, et al. Malar J. 2018 Mar 9;17(1):106. doi: 10.1186/s12936-018-2258-9. Malar J. 2018. PMID: 29523137 Free PMC article.
34 results