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1,3-Dioxane-Linked Bacterial Topoisomerase Inhibitors with Enhanced Antibacterial Activity and Reduced hERG Inhibition.
Li L, Okumu AA, Nolan S, English A, Vibhute S, Lu Y, Hervert-Thomas K, Seffernick JT, Azap L, Cole SL, Shinabarger D, Koeth LM, Lindert S, Yalowich JC, Wozniak DJ, Mitton-Fry MJ. Li L, et al. Among authors: seffernick jt. ACS Infect Dis. 2019 Jul 12;5(7):1115-1128. doi: 10.1021/acsinfecdis.8b00375. Epub 2019 May 9. ACS Infect Dis. 2019. PMID: 31041863
Relative interfacial cleavage energetics of protein complexes revealed by surface collisions.
Harvey SR, Seffernick JT, Quintyn RS, Song Y, Ju Y, Yan J, Sahasrabuddhe AN, Norris A, Zhou M, Behrman EJ, Lindert S, Wysocki VH. Harvey SR, et al. Among authors: seffernick jt. Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8143-8148. doi: 10.1073/pnas.1817632116. Epub 2019 Apr 3. Proc Natl Acad Sci U S A. 2019. PMID: 30944216 Free PMC article.
Integrated Use of Biochemical, Native Mass Spectrometry, Computational, and Genome-Editing Methods to Elucidate the Mechanism of a Salmonella deglycase.
Sengupta A, Wu J, Seffernick JT, Sabag-Daigle A, Thomsen N, Chen TH, Capua AD, Bell CE, Ahmer BMM, Lindert S, Wysocki VH, Gopalan V. Sengupta A, et al. Among authors: seffernick jt. J Mol Biol. 2019 Nov 8;431(22):4497-4513. doi: 10.1016/j.jmb.2019.08.017. Epub 2019 Sep 4. J Mol Biol. 2019. PMID: 31493410 Free PMC article.
Dioxane-Linked Amide Derivatives as Novel Bacterial Topoisomerase Inhibitors against Gram-Positive Staphylococcus aureus.
Lu Y, Papa JL, Nolan S, English A, Seffernick JT, Shkolnikov N, Powell J, Lindert S, Wozniak DJ, Yalowich J, Mitton-Fry MJ. Lu Y, et al. Among authors: seffernick jt. ACS Med Chem Lett. 2020 Oct 19;11(12):2446-2454. doi: 10.1021/acsmedchemlett.0c00428. eCollection 2020 Dec 10. ACS Med Chem Lett. 2020. PMID: 33335666 Free PMC article.
Binding of calcium and magnesium to human cardiac troponin C.
Rayani K, Seffernick J, Li AY, Davis JP, Spuches AM, Van Petegem F, Solaro RJ, Lindert S, Tibbits GF. Rayani K, et al. J Biol Chem. 2021 Jan-Jun;296:100350. doi: 10.1016/j.jbc.2021.100350. Epub 2021 Feb 3. J Biol Chem. 2021. PMID: 33548225 Free PMC article.
19 results