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Page 1
1,3-Dioxane-Linked Bacterial Topoisomerase Inhibitors with Enhanced Antibacterial Activity and Reduced hERG Inhibition.
Li L, Okumu AA, Nolan S, English A, Vibhute S, Lu Y, Hervert-Thomas K, Seffernick JT, Azap L, Cole SL, Shinabarger D, Koeth LM, Lindert S, Yalowich JC, Wozniak DJ, Mitton-Fry MJ. Li L, et al. Among authors: okumu aa. ACS Infect Dis. 2019 Jul 12;5(7):1115-1128. doi: 10.1021/acsinfecdis.8b00375. Epub 2019 May 9. ACS Infect Dis. 2019. PMID: 31041863
Novel bacterial topoisomerase inhibitors derived from isomannide.
Okumu A, Lu Y, Dellos-Nolan S, Papa JL, Koci B, Cockroft NT, Gallucci J, Wozniak DJ, Yalowich JC, Mitton-Fry MJ. Okumu A, et al. Eur J Med Chem. 2020 Aug 1;199:112324. doi: 10.1016/j.ejmech.2020.112324. Epub 2020 Apr 28. Eur J Med Chem. 2020. PMID: 32402932
Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with In Vivo Efficacy against MRSA.
Lu Y, Vibhute S, Li L, Okumu A, Ratigan SC, Nolan S, Papa JL, Mann CA, English A, Chen A, Seffernick JT, Koci B, Duncan LR, Roth B, Cummings JE, Slayden RA, Lindert S, McElroy CA, Wozniak DJ, Yalowich J, Mitton-Fry MJ. Lu Y, et al. J Med Chem. 2021 Oct 28;64(20):15214-15249. doi: 10.1021/acs.jmedchem.1c01250. Epub 2021 Oct 6. J Med Chem. 2021. PMID: 34614347
Synthesis of the C22-C40 Domain of the Azaspiracids.
Zhang Z, Chen Y, Adu-Ampratwum D, Okumu AA, Kenton NT, Forsyth CJ. Zhang Z, et al. Among authors: okumu aa. Org Lett. 2016 Apr 15;18(8):1824-7. doi: 10.1021/acs.orglett.6b00557. Epub 2016 Apr 4. Org Lett. 2016. PMID: 27043010
Stereochemical Definition of the Natural Product (6R,10R,13R, 14R,16R,17R,19S,20S,21R,24S,25S,28S,30S,32R,33R,34R,36S,37S,39R)-Azaspiracid-3 by Total Synthesis and Comparative Analyses.
Kenton NT, Adu-Ampratwum D, Okumu AA, McCarron P, Kilcoyne J, Rise F, Wilkins AL, Miles CO, Forsyth CJ. Kenton NT, et al. Among authors: okumu aa. Angew Chem Int Ed Engl. 2018 Jan 15;57(3):810-813. doi: 10.1002/anie.201711008. Epub 2017 Dec 15. Angew Chem Int Ed Engl. 2018. PMID: 29193497
Total Synthesis of (6R,10R,13R,14R,16R,17R,19S,20R,21R,24S, 25S,28S,30S,32R,33R,34R,36S,37S,39R)-Azaspiracid-3 Reveals Non-Identity with the Natural Product.
Kenton NT, Adu-Ampratwum D, Okumu AA, Zhang Z, Chen Y, Nguyen S, Xu J, Ding Y, McCarron P, Kilcoyne J, Rise F, Wilkins AL, Miles CO, Forsyth CJ. Kenton NT, et al. Among authors: okumu aa. Angew Chem Int Ed Engl. 2018 Jan 15;57(3):805-809. doi: 10.1002/anie.201711006. Epub 2017 Dec 13. Angew Chem Int Ed Engl. 2018. PMID: 29193614