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Switching Aurora-A kinase on and off at an allosteric site.
Bayliss R, Burgess SG, McIntyre PJ. Bayliss R, et al. Among authors: mcintyre pj. FEBS J. 2017 Sep;284(18):2947-2954. doi: 10.1111/febs.14069. Epub 2017 Apr 18. FEBS J. 2017. PMID: 28342286 Free article. Review.
Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
McIntyre PJ, Collins PM, Vrzal L, Birchall K, Arnold LH, Mpamhanga C, Coombs PJ, Burgess SG, Richards MW, Winter A, Veverka V, Delft FV, Merritt A, Bayliss R. McIntyre PJ, et al. ACS Chem Biol. 2017 Nov 17;12(11):2906-2914. doi: 10.1021/acschembio.7b00537. Epub 2017 Oct 30. ACS Chem Biol. 2017. PMID: 29045126 Free article.
7-(Pyrazol-4-yl)-3H-imidazo[4,5-b]pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation of the pyrazole N1-substituent.
Bavetsias V, Pérez-Fuertes Y, McIntyre PJ, Atrash B, Kosmopoulou M, O'Fee L, Burke R, Sun C, Faisal A, Bush K, Avery S, Henley A, Raynaud FI, Linardopoulos S, Bayliss R, Blagg J. Bavetsias V, et al. Among authors: mcintyre pj. Bioorg Med Chem Lett. 2015 Oct 1;25(19):4203-9. doi: 10.1016/j.bmcl.2015.08.003. Epub 2015 Aug 6. Bioorg Med Chem Lett. 2015. PMID: 26296477 Free PMC article.
An Integrated Quantitative Index for Measuring Chronic Multisite Pain: The Multiple Areas of Pain (MAP) Study.
Wallace MS, North J, Grigsby EJ, Kapural L, Sanapati MR, Smith SG, Willoughby C, McIntyre PJ, Cohen SP, Rosenthal RM, Ahmed S, Vallejo R, Ahadian FM, Yearwood TL, Burton AW, Frankoski EJ, Shetake J, Lin S, Hershey B, Rogers B, Mekel-Bobrov N. Wallace MS, et al. Among authors: mcintyre pj. Pain Med. 2018 Jul 1;19(7):1425-1435. doi: 10.1093/pm/pnx325. Pain Med. 2018. PMID: 29474648
16 results