Appu AP - Search Results

1

Cln3-mutations underlying juvenile neuronal ceroid lipofuscinosis cause significantly reduced levels of Palmitoyl-protein thioesterases-1 (Ppt1)-protein and Ppt1-enzyme activity in the lysosome.

Appu AP, Bagh MB, Sadhukhan T, Mondal A, Casey S, Mukherjee AB. Appu AP, et al. J Inherit Metab Dis. 2019 Sep;42(5):944-954. doi: 10.1002/jimd.12106. Epub 2019 May 14. J Inherit Metab Dis. 2019. PMID: 31025705 Free PMC article.

2

Emerging new roles of the lysosome and neuronal ceroid lipofuscinoses.

Mukherjee AB, Appu AP, Sadhukhan T, Casey S, Mondal A, Zhang Z, Bagh MB. Mukherjee AB, et al. Among authors: appu ap. Mol Neurodegener. 2019 Jan 16;14(1):4. doi: 10.1186/s13024-018-0300-6. Mol Neurodegener. 2019. PMID: 30651094 Free PMC article. Review.

3

Cln1-mutations suppress Rab7-RILP interaction and impair autophagy contributing to neuropathology in a mouse model of infantile neuronal ceroid lipofuscinosis.

Sarkar C, Sadhukhan T, Bagh MB, Appu AP, Chandra G, Mondal A, Saha A, Mukherjee AB. Sarkar C, et al. Among authors: appu ap. J Inherit Metab Dis. 2020 Sep;43(5):1082-1101. doi: 10.1002/jimd.12242. Epub 2020 Apr 27. J Inherit Metab Dis. 2020. PMID: 32279353 Free PMC article.

4

In a mouse model of INCL reduced S-palmitoylation of cytosolic thioesterase APT1 contributes to microglia proliferation and neuroinflammation.

Sadhukhan T, Bagh MB, Appu AP, Mondal A, Zhang W, Liu A, Mukherjee AB. Sadhukhan T, et al. Among authors: appu ap. J Inherit Metab Dis. 2021 Jul;44(4):1051-1069. doi: 10.1002/jimd.12379. Epub 2021 Mar 29. J Inherit Metab Dis. 2021. PMID: 33739454

5

Ablation of microRNA-155 and neuroinflammation in a mouse model of CLN1-disease.

Sadhukhan T, Bagh MB, Sadhukhan S, Appu AP, Mondal A, Iiben JR, Li T, Coon SL, Mukherjee AB. Sadhukhan T, et al. Among authors: appu ap. Biochem Biophys Res Commun. 2021 Sep 24;571:137-144. doi: 10.1016/j.bbrc.2021.07.057. Epub 2021 Jul 26. Biochem Biophys Res Commun. 2021. PMID: 34325129

6

Ppt1-deficiency dysregulates lysosomal Ca⁺⁺ homeostasis contributing to pathogenesis in a mouse model of CLN1 disease.

Mondal A, Appu AP, Sadhukhan T, Bagh MB, Previde RM, Sadhukhan S, Stojilkovic S, Liu A, Mukherjee AB. Mondal A, et al. Among authors: appu ap. J Inherit Metab Dis. 2022 May;45(3):635-656. doi: 10.1002/jimd.12485. Epub 2022 Mar 17. J Inherit Metab Dis. 2022. PMID: 35150145 Free PMC article.

7

Acss2 Deletion Reveals Functional Versatility via Tissue-Specific Roles in Transcriptional Regulation.

Vasudevan NP, Soni DK, Moffett JR, Krishnan JKS, Appu AP, Ghoshal S, Arun P, Denu JM, Flagg TP, Biswas R, Namboodiri AM. Vasudevan NP, et al. Among authors: appu ap. Int J Mol Sci. 2023 Feb 12;24(4):3673. doi: 10.3390/ijms24043673. Int J Mol Sci. 2023. PMID: 36835088 Free PMC article.

8

Increasing N-acetylaspartate in the Brain during Postnatal Myelination Does Not Cause the CNS Pathologies of Canavan Disease.

Appu AP, Moffett JR, Arun P, Moran S, Nambiar V, Krishnan JKS, Puthillathu N, Namboodiri AMA. Appu AP, et al. Front Mol Neurosci. 2017 Jun 2;10:161. doi: 10.3389/fnmol.2017.00161. eCollection 2017. Front Mol Neurosci. 2017. PMID: 28626388 Free PMC article.

9

Rapid intranasal delivery of chloramphenicol acetyltransferase in the active form to different brain regions as a model for enzyme therapy in the CNS.

Appu AP, Arun P, Krishnan JKS, Moffett JR, Namboodiri AMA. Appu AP, et al. J Neurosci Methods. 2016 Feb 1;259:129-134. doi: 10.1016/j.jneumeth.2015.11.027. Epub 2015 Dec 10. J Neurosci Methods. 2016. PMID: 26688469 Free PMC article.

10

Intranasal delivery of obidoxime to the brain prevents mortality and CNS damage from organophosphate poisoning.

Krishnan JKS, Arun P, Appu AP, Vijayakumar N, Figueiredo TH, Braga MFM, Baskota S, Olsen CH, Farkas N, Dagata J, Frey WH 2nd, Moffett JR, Namboodiri AMA. Krishnan JKS, et al. Among authors: appu ap. Neurotoxicology. 2016 Mar;53:64-73. doi: 10.1016/j.neuro.2015.12.020. Epub 2016 Jan 2. Neurotoxicology. 2016. PMID: 26751814 Free PMC article.

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