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Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A.
Toretsky JA, Erkizan V, Levenson A, Abaan OD, Parvin JD, Cripe TP, Rice AM, Lee SB, Uren A. Toretsky JA, et al. Cancer Res. 2006 Jun 1;66(11):5574-81. doi: 10.1158/0008-5472.CAN-05-3293. Cancer Res. 2006. PMID: 16740692
GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein.
Beauchamp E, Bulut G, Abaan O, Chen K, Merchant A, Matsui W, Endo Y, Rubin JS, Toretsky J, Uren A. Beauchamp E, et al. J Biol Chem. 2009 Apr 3;284(14):9074-82. doi: 10.1074/jbc.M806233200. Epub 2009 Feb 3. J Biol Chem. 2009. PMID: 19189974 Free PMC article.
Single enantiomer of YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1.
Barber-Rotenberg JS, Selvanathan SP, Kong Y, Erkizan HV, Snyder TM, Hong SP, Kobs CL, South NL, Summer S, Monroe PJ, Chruszcz M, Dobrev V, Tosso PN, Scher LJ, Minor W, Brown ML, Metallo SJ, Üren A, Toretsky JA. Barber-Rotenberg JS, et al. Among authors: toretsky ja. Oncotarget. 2012 Feb;3(2):172-82. doi: 10.18632/oncotarget.454. Oncotarget. 2012. PMID: 22383402 Free PMC article.
Hypoxia shifts activity of neuropeptide Y in Ewing sarcoma from growth-inhibitory to growth-promoting effects.
Tilan JU, Lu C, Galli S, Izycka-Swieszewska E, Earnest JP, Shabbir A, Everhart LM, Wang S, Martin S, Horton M, Mahajan A, Christian D, O'Neill A, Wang H, Zhuang T, Czarnecka M, Johnson MD, Toretsky JA, Kitlinska J. Tilan JU, et al. Among authors: toretsky ja. Oncotarget. 2013 Dec;4(12):2487-501. doi: 10.18632/oncotarget.1604. Oncotarget. 2013. PMID: 24318733 Free PMC article.
126 results