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RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1.
Mill CP, Fiskus W, DiNardo CD, Qian Y, Raina K, Rajapakshe K, Perera D, Coarfa C, Kadia TM, Khoury JD, Saenz DT, Saenz DN, Illendula A, Takahashi K, Kornblau SM, Green MR, Futreal AP, Bushweller JH, Crews CM, Bhalla KN. Mill CP, et al. Among authors: takahashi k. Blood. 2019 Jul 4;134(1):59-73. doi: 10.1182/blood.2018893982. Epub 2019 Apr 25. Blood. 2019. PMID: 31023702 Free PMC article.
Acquisition of cytogenetic abnormalities in patients with IPSS defined lower-risk myelodysplastic syndrome is associated with poor prognosis and transformation to acute myelogenous leukemia.
Jabbour E, Takahashi K, Wang X, Cornelison AM, Abruzzo L, Kadia T, Borthakur G, Estrov Z, O'Brien S, Mallo M, Wierda W, Pierce S, Wei Y, Sole F, Chen R, Kantarjian H, Garcia-Manero G. Jabbour E, et al. Among authors: takahashi k. Am J Hematol. 2013 Oct;88(10):831-7. doi: 10.1002/ajh.23513. Epub 2013 Jul 23. Am J Hematol. 2013. PMID: 23760779 Free PMC article. Clinical Trial.
Clonal evolution of acute myeloid leukemia relapsed after 19 years of remission.
Takahashi K, Roh W, Zhang J, Propotopov A, Patel K, Strickland S, Kim A, Vnencak-Jones C, Pelletier S, Parmar S, Garcia-Manero G, Kornblau S, Chin L, Kantarjian H, Futreal PA, Ravandi F. Takahashi K, et al. Am J Hematol. 2015 Jul;90(7):E134-5. doi: 10.1002/ajh.24009. Am J Hematol. 2015. PMID: 25801490 Free PMC article. No abstract available.
Characteristics, clinical outcome, and prognostic significance of IDH mutations in AML.
DiNardo CD, Ravandi F, Agresta S, Konopleva M, Takahashi K, Kadia T, Routbort M, Patel KP, Mark Brandt, Pierce S, Garcia-Manero G, Cortes J, Kantarjian H. DiNardo CD, et al. Among authors: takahashi k. Am J Hematol. 2015 Aug;90(8):732-6. doi: 10.1002/ajh.24072. Am J Hematol. 2015. PMID: 26016821 Free PMC article.
IDH1 and IDH2 mutations in myelodysplastic syndromes and role in disease progression.
DiNardo CD, Jabbour E, Ravandi F, Takahashi K, Daver N, Routbort M, Patel KP, Brandt M, Pierce S, Kantarjian H, Garcia-Manero G. DiNardo CD, et al. Among authors: takahashi k. Leukemia. 2016 Apr;30(4):980-4. doi: 10.1038/leu.2015.211. Epub 2015 Jul 31. Leukemia. 2016. PMID: 26228814 Free PMC article. No abstract available.
Detectable FLT3-ITD or RAS mutation at the time of transformation from MDS to AML predicts for very poor outcomes.
Badar T, Patel KP, Thompson PA, DiNardo C, Takahashi K, Cabrero M, Borthakur G, Cortes J, Konopleva M, Kadia T, Bohannan Z, Pierce S, Jabbour EJ, Ravandi F, Daver N, Luthra R, Kantarjian H, Garcia-Manero G. Badar T, et al. Among authors: takahashi k. Leuk Res. 2015 Dec;39(12):1367-74. doi: 10.1016/j.leukres.2015.10.005. Epub 2015 Oct 19. Leuk Res. 2015. PMID: 26547258 Free PMC article.
Clofarabine Plus Low-Dose Cytarabine Is as Effective as and Less Toxic Than Intensive Chemotherapy in Elderly AML Patients.
Takahashi K, Kantarjian H, Garcia-Manero G, Borthakur G, Kadia T, DiNardo C, Jabbour E, Pierce S, Estrov Z, Konopleva M, Andreeff M, Ravandi F, Cortes J. Takahashi K, et al. Clin Lymphoma Myeloma Leuk. 2016 Mar;16(3):163-8.e1-2. doi: 10.1016/j.clml.2015.11.016. Epub 2015 Nov 24. Clin Lymphoma Myeloma Leuk. 2016. PMID: 26752456 Free PMC article.
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