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H3F3A mutation in giant cell tumour of the bone is detected by immunohistochemistry using a monoclonal antibody against the G34W mutated site of the histone H3.3 variant.
Lüke J, von Baer A, Schreiber J, Lübbehüsen C, Breining T, Mellert K, Marienfeld R, Schultheiss M, Möller P, Barth TFE. Lüke J, et al. Among authors: lubbehusen c. Histopathology. 2017 Jul;71(1):125-133. doi: 10.1111/his.13190. Epub 2017 Apr 10. Histopathology. 2017. PMID: 28211081