Activation of ROS/MAPKs/NF-κB/NLRP3 and inhibition of efferocytosis in osteoclast-mediated diabetic osteoporosis.
An Y, Zhang H, Wang C, Jiao F, Xu H, Wang X, Luan W, Ma F, Ni L, Tang X, Liu M, Guo W, Yu L.
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FASEB J. 2019 Nov;33(11):12515-12527. doi: 10.1096/fj.201802805RR. Epub 2019 Aug 28.
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PMID: 31461386
Free PMC article.
Further analysis showed that in HG-induced OCs, ROS is an upstream signal for MAPKs, NF-kappaB, and the NLRP3 inflammasome. Moreover, MAPKs mediated the activation of NF-kappaB and NLRP3, whereas NF-kappaB up-regulated the NLRP3 inflammasome response. ...Together, these re …
Further analysis showed that in HG-induced OCs, ROS is an upstream signal for MAPKs, NF-kappaB, and the NLRP3 inflammasome. Moreover, …