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Phenolic compounds as Nrf2 inhibitors: potential applications in cancer therapy.
Sharifi-Rad J, Seidel V, Izabela M, Monserrat-Mequida M, Sureda A, Ormazabal V, Zuniga FA, Mangalpady SS, Pezzani R, Ydyrys A, Tussupbekova G, Martorell M, Calina D, Cho WC. Sharifi-Rad J, et al. Among authors: zuniga fa. Cell Commun Signal. 2023 May 1;21(1):89. doi: 10.1186/s12964-023-01109-0. Cell Commun Signal. 2023. PMID: 37127651 Free PMC article. Review.
Mechanistic insights and functional determinants of the transport cycle of the ascorbic acid transporter SVCT2. Activation by sodium and absolute dependence on bivalent cations.
Godoy A, Ormazabal V, Moraga-Cid G, Zúñiga FA, Sotomayor P, Barra V, Vasquez O, Montecinos V, Mardones L, Guzmán C, Villagrán M, Aguayo LG, Oñate SA, Reyes AM, Cárcamo JG, Rivas CI, Vera JC. Godoy A, et al. Among authors: zuniga fa. J Biol Chem. 2007 Jan 5;282(1):615-24. doi: 10.1074/jbc.M608300200. Epub 2006 Sep 29. J Biol Chem. 2007. PMID: 17012227 Free article.
Histidine residues in the Na+-coupled ascorbic acid transporter-2 (SVCT2) are central regulators of SVCT2 function, modulating pH sensitivity, transporter kinetics, Na+ cooperativity, conformational stability, and subcellular localization.
Ormazabal V, Zuñiga FA, Escobar E, Aylwin C, Salas-Burgos A, Godoy A, Reyes AM, Vera JC, Rivas CI. Ormazabal V, et al. Among authors: zuniga fa. J Biol Chem. 2010 Nov 19;285(47):36471-85. doi: 10.1074/jbc.M110.155630. Epub 2010 Sep 14. J Biol Chem. 2010. PMID: 20843809 Free PMC article.
Essential role of intracellular glutathione in controlling ascorbic acid transporter expression and function in rat hepatocytes and hepatoma cells.
Mardones L, Zúñiga FA, Villagrán M, Sotomayor K, Mendoza P, Escobar D, González M, Ormazabal V, Maldonado M, Oñate G, Angulo C, Concha II, Reyes AM, Cárcamo JG, Barra V, Vera JC, Rivas CI. Mardones L, et al. Among authors: zuniga fa. Free Radic Biol Med. 2012 May 1;52(9):1874-87. doi: 10.1016/j.freeradbiomed.2012.02.017. Epub 2012 Feb 18. Free Radic Biol Med. 2012. PMID: 22348976
38 results