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Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription.
Gao R, Chakraborty A, Geater C, Pradhan S, Gordon KL, Snowden J, Yuan S, Dickey AS, Choudhary S, Ashizawa T, Ellerby LM, La Spada AR, Thompson LM, Hazra TK, Sarkar PS. Gao R, et al. Among authors: pradhan s. Elife. 2019 Apr 17;8:e42988. doi: 10.7554/eLife.42988. Elife. 2019. PMID: 30994454 Free PMC article.
PIAS1 modulates striatal transcription, DNA damage repair, and SUMOylation with relevance to Huntington's disease.
Morozko EL, Smith-Geater C, Monteys AM, Pradhan S, Lim RG, Langfelder P, Kachemov M, Kulkarni JA, Zaifman J, Hill A, Stocksdale JT, Cullis PR, Wu J, Ochaba J, Miramontes R, Chakraborty A, Hazra TK, Lau A, St-Cyr S, Orellana I, Kopan L, Wang KQ, Yeung S, Leavitt BR, Reidling JC, Yang XW, Steffan JS, Davidson BL, Sarkar PS, Thompson LM. Morozko EL, et al. Among authors: pradhan s. Proc Natl Acad Sci U S A. 2021 Jan 26;118(4):e2021836118. doi: 10.1073/pnas.2021836118. Proc Natl Acad Sci U S A. 2021. PMID: 33468657 Free PMC article.
Chromatin remodeler BRG1 recruits huntingtin to repair DNA double-strand breaks in neurons.
Pradhan S, Bush K, Zhang N, Pandita RK, Tsai CL, Smith C, Pandlebury DF, Gaikwad S, Leonard F, Nie L, Tao A, Russell W, Yuan S, Choudhary S, Ramos KS, Elferink C, Wairkar YP, Tainer JA, Thompson LM, Pandita TK, Sarkar PS. Pradhan S, et al. bioRxiv [Preprint]. 2024 Sep 20:2024.09.19.613927. doi: 10.1101/2024.09.19.613927. bioRxiv. 2024. PMID: 39345557 Free PMC article. Preprint.
Single (375 mg/m2) vs. double dose of rituximab along with mycophenolate mofetil for children with steroid-dependent/frequently relapsing nephrotic syndrome: a multicentre open-label randomized controlled trial.
Sinha R, Pradhan S, Raut S, Banerjee S, Sarkar S, Akhtar S, Dasgupta D, Poddar S, Mandal M, Kamal VK, Chaudhury AR, Tse Y. Sinha R, et al. Among authors: pradhan s. Pediatr Nephrol. 2024 Dec 27. doi: 10.1007/s00467-024-06619-8. Online ahead of print. Pediatr Nephrol. 2024. PMID: 39729126
2,124 results