Whitworth AJ - Search Results

1

Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction.

von Stockum S, Sanchez-Martinez A, Corrà S, Chakraborty J, Marchesan E, Locatello L, Da Rè C, Cusumano P, Caicci F, Ferrari V, Costa R, Bubacco L, Rasotto MB, Szabo I, Whitworth AJ, Scorrano L, Ziviani E. von Stockum S, et al. Among authors: whitworth aj. Life Sci Alliance. 2019 Apr 15;2(2):e201900392. doi: 10.26508/lsa.201900392. Print 2019 Apr. Life Sci Alliance. 2019. PMID: 30988163 Free PMC article.

2

Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin.

Tain LS, Chowdhury RB, Tao RN, Plun-Favreau H, Moisoi N, Martins LM, Downward J, Whitworth AJ, Tapon N. Tain LS, et al. Among authors: whitworth aj. Cell Death Differ. 2009 Aug;16(8):1118-25. doi: 10.1038/cdd.2009.23. Epub 2009 Mar 13. Cell Death Differ. 2009. PMID: 19282869 Free PMC article.

3

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss.

Tain LS, Mortiboys H, Tao RN, Ziviani E, Bandmann O, Whitworth AJ. Tain LS, et al. Among authors: whitworth aj. Nat Neurosci. 2009 Sep;12(9):1129-35. doi: 10.1038/nn.2372. Epub 2009 Aug 16. Nat Neurosci. 2009. PMID: 19684592 Free PMC article.

4

Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin.

Ziviani E, Tao RN, Whitworth AJ. Ziviani E, et al. Among authors: whitworth aj. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5018-23. doi: 10.1073/pnas.0913485107. Epub 2010 Mar 1. Proc Natl Acad Sci U S A. 2010. PMID: 20194754 Free PMC article.

5

How could Parkin-mediated ubiquitination of mitofusin promote mitophagy?

Ziviani E, Whitworth AJ. Ziviani E, et al. Among authors: whitworth aj. Autophagy. 2010 Jul;6(5):660-2. doi: 10.4161/auto.6.5.12242. Epub 2010 Jul 1. Autophagy. 2010. PMID: 20484985 Free PMC article.

6

Modeling pathogenic mutations of human twinkle in Drosophila suggests an apoptosis role in response to mitochondrial defects.

Sanchez-Martinez A, Calleja M, Peralta S, Matsushima Y, Hernandez-Sierra R, Whitworth AJ, Kaguni LS, Garesse R. Sanchez-Martinez A, et al. Among authors: whitworth aj. PLoS One. 2012;7(8):e43954. doi: 10.1371/journal.pone.0043954. Epub 2012 Aug 28. PLoS One. 2012. PMID: 22952820 Free PMC article.

7

The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.

Burchell VS, Nelson DE, Sanchez-Martinez A, Delgado-Camprubi M, Ivatt RM, Pogson JH, Randle SJ, Wray S, Lewis PA, Houlden H, Abramov AY, Hardy J, Wood NW, Whitworth AJ, Laman H, Plun-Favreau H. Burchell VS, et al. Among authors: whitworth aj. Nat Neurosci. 2013 Sep;16(9):1257-65. doi: 10.1038/nn.3489. Epub 2013 Aug 11. Nat Neurosci. 2013. PMID: 23933751 Free PMC article.

8

Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy.

Ivatt RM, Sanchez-Martinez A, Godena VK, Brown S, Ziviani E, Whitworth AJ. Ivatt RM, et al. Among authors: whitworth aj. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8494-9. doi: 10.1073/pnas.1321207111. Epub 2014 May 27. Proc Natl Acad Sci U S A. 2014. PMID: 24912190 Free PMC article.

9

The complex I subunit NDUFA10 selectively rescues Drosophila pink1 mutants through a mechanism independent of mitophagy.

Pogson JH, Ivatt RM, Sanchez-Martinez A, Tufi R, Wilson E, Mortiboys H, Whitworth AJ. Pogson JH, et al. Among authors: whitworth aj. PLoS Genet. 2014 Nov 20;10(11):e1004815. doi: 10.1371/journal.pgen.1004815. eCollection 2014 Nov. PLoS Genet. 2014. PMID: 25412178 Free PMC article.

10

Superoxide Dismutase (SOD)-mimetic M40403 Is Protective in Cell and Fly Models of Paraquat Toxicity: IMPLICATIONS FOR PARKINSON DISEASE.

Filograna R, Godena VK, Sanchez-Martinez A, Ferrari E, Casella L, Beltramini M, Bubacco L, Whitworth AJ, Bisaglia M. Filograna R, et al. Among authors: whitworth aj. J Biol Chem. 2016 Apr 22;291(17):9257-67. doi: 10.1074/jbc.M115.708057. Epub 2016 Mar 7. J Biol Chem. 2016. PMID: 26953346 Free PMC article.

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