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Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLCε-NF-κB signaling pathway and VEGF-C/ Bcl-2 expression.
Chen Y, Wang D, Peng H, Chen X, Han X, Yu J, Wang W, Liang L, Liu Z, Zheng Y, Hu J, Yang L, Li J, Zhou H, Cui X, Li F. Chen Y, et al. Among authors: chen x. Mol Cancer. 2019 Jan 4;18(1):1. doi: 10.1186/s12943-018-0930-x. Mol Cancer. 2019. PMID: 30609930 Free PMC article.
Hypomethylation-Linked Activation of PLCE1 Impedes Autophagy and Promotes Tumorigenesis through MDM2-Mediated Ubiquitination and Destabilization of p53.
Chen Y, Xin H, Peng H, Shi Q, Li M, Yu J, Tian Y, Han X, Chen X, Zheng Y, Li J, Yang Z, Yang L, Hu J, Huang X, Liu Z, Huang X, Zhou H, Cui X, Li F. Chen Y, et al. Among authors: chen x. Cancer Res. 2020 Jun 1;80(11):2175-2189. doi: 10.1158/0008-5472.CAN-19-1912. Epub 2020 Feb 17. Cancer Res. 2020. PMID: 32066565
Tumor cell-intrinsic PD-1 receptor is a tumor suppressor and mediates resistance to PD-1 blockade therapy.
Wang X, Yang X, Zhang C, Wang Y, Cheng T, Duan L, Tong Z, Tan S, Zhang H, Saw PE, Gu Y, Wang J, Zhang Y, Shang L, Liu Y, Jiang S, Yan B, Li R, Yang Y, Yu J, Chen Y, Gao GF, Ye Q, Gao S. Wang X, et al. Among authors: chen y. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6640-6650. doi: 10.1073/pnas.1921445117. Epub 2020 Mar 11. Proc Natl Acad Sci U S A. 2020. PMID: 32161124 Free PMC article.
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