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Inhibitors of signal peptide peptidase and subtilisin/kexin-isozyme 1 inhibit Ebola virus glycoprotein-driven cell entry by interfering with activity and cellular localization of endosomal cathepsins.
Plegge T, Spiegel M, Krüger N, Nehlmeier I, Winkler M, González Hernández M, Pöhlmann S. Plegge T, et al. Among authors: winkler m. PLoS One. 2019 Apr 11;14(4):e0214968. doi: 10.1371/journal.pone.0214968. eCollection 2019. PLoS One. 2019. PMID: 30973897 Free PMC article.
The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies.
Gierer S, Bertram S, Kaup F, Wrensch F, Heurich A, Krämer-Kühl A, Welsch K, Winkler M, Meyer B, Drosten C, Dittmer U, von Hahn T, Simmons G, Hofmann H, Pöhlmann S. Gierer S, et al. Among authors: winkler m. J Virol. 2013 May;87(10):5502-11. doi: 10.1128/JVI.00128-13. Epub 2013 Mar 6. J Virol. 2013. PMID: 23468491 Free PMC article.
TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium.
Bertram S, Dijkman R, Habjan M, Heurich A, Gierer S, Glowacka I, Welsch K, Winkler M, Schneider H, Hofmann-Winkler H, Thiel V, Pöhlmann S. Bertram S, et al. Among authors: winkler m. J Virol. 2013 Jun;87(11):6150-60. doi: 10.1128/JVI.03372-12. Epub 2013 Mar 27. J Virol. 2013. PMID: 23536651 Free PMC article.
Rhesus macaque IFITM3 gene polymorphisms and SIV infection.
Winkler M, Gärtner S, Wrensch F, Krawczak M, Sauermann U, Pöhlmann S. Winkler M, et al. PLoS One. 2017 Mar 3;12(3):e0172847. doi: 10.1371/journal.pone.0172847. eCollection 2017. PLoS One. 2017. PMID: 28257482 Free PMC article.
1,807 results