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Metabolism of the dual FLT-3/Aurora kinase inhibitor CCT241736 in preclinical and human in vitro models: Implication for the choice of toxicology species.
Wood FL, Shepherd S, Hayes A, Liu M, Grira K, Mok Y, Atrash B, Faisal A, Bavetsias V, Linardopoulos S, Blagg J, Raynaud FI. Wood FL, et al. Among authors: shepherd s. Eur J Pharm Sci. 2019 Nov 1;139:104899. doi: 10.1016/j.ejps.2019.04.004. Epub 2019 Apr 3. Eur J Pharm Sci. 2019. PMID: 30953752 Free PMC article.
Small RNAs control sodium channel expression, nociceptor excitability, and pain thresholds.
Zhao J, Lee MC, Momin A, Cendan CM, Shepherd ST, Baker MD, Asante C, Bee L, Bethry A, Perkins JR, Nassar MA, Abrahamsen B, Dickenson A, Cobb BS, Merkenschlager M, Wood JN. Zhao J, et al. Among authors: shepherd st. J Neurosci. 2010 Aug 11;30(32):10860-71. doi: 10.1523/JNEUROSCI.1980-10.2010. J Neurosci. 2010. PMID: 20702715 Free PMC article.
Tracking Nongenetic Evolution from Primary to Metastatic ccRCC: TRACERx Renal.
Fernández-Sanromán Á, Fendler A, Tan BJY, Cattin AL, Spencer C, Thompson R, Au L, Lobon I, Pallikonda HA, Martin A, Byrne F, Franz A, Mikolajczak A, Rahman H, Tippu Z, Shepherd STC, Feng H, Deng D, Rowan A, Pickering L, Furness AJS, Young K, Nicol D, Rudman SM, O'Brien T, Edmonds K, Chandra A, Hazell S, Litchfield K, Kassiotis G, Larkin J, Turajlic S. Fernández-Sanromán Á, et al. Among authors: shepherd stc. Cancer Discov. 2025 Jan 9:OF1-OF23. doi: 10.1158/2159-8290.CD-24-0499. Online ahead of print. Cancer Discov. 2025. PMID: 39784160
Tracking non-genetic evolution from primary to metastatic ccRCC: TRACERx Renal.
Fernández-Sanromán Á, Fendler A, Tan BJY, Cattin AL, Spencer C, Thompson R, Au L, Lobon I, Pallikonda HA, Martin A, Byrne F, Franz A, Mikolajczak A, Rahman H, Tippu Z, Shepherd STC, Feng H, Deng D, Rowan A, Pickering L, Furness AJS, Young K, Nicol D, Rudman SM, O'Brien T, Edmonds K, Chandra A, Hazell S, Litchfield K, Kassiotis G, Larkin J, Turajlic S. Fernández-Sanromán Á, et al. Among authors: shepherd stc. Cancer Discov. 2025 Jan 8. doi: 10.1158/2159-8290.CD-24-0499. Online ahead of print. Cancer Discov. 2025. PMID: 39774619
Solution biophysics identifies lipid nanoparticle non-sphericity, polydispersity, and dependence on internal ordering for efficacious mRNA delivery.
Padilla MS, Shepherd SJ, Hanna AR, Kurnik M, Zhang X, Chen M, Byrnes J, Yamagata HM, Ricciardi A, Joseph RA, Mrksich K, Issadore D, Gupta K, Mitchell MJ. Padilla MS, et al. Among authors: shepherd sj. bioRxiv [Preprint]. 2024 Dec 22:2024.12.19.629496. doi: 10.1101/2024.12.19.629496. bioRxiv. 2024. PMID: 39763759 Free PMC article. Preprint.
Pharmacological and structural understanding of the Trypanosoma cruzi proteasome provides key insights for developing site-specific inhibitors.
Eadsforth TC, Torrie LS, Rowland P, Edgar EV, MacLean LM, Paterson C, Robinson DA, Shepherd SM, Thomas J, Thomas MG, Gray DW, Postis VLG, De Rycker M. Eadsforth TC, et al. Among authors: shepherd sm. J Biol Chem. 2024 Dec 9;301(1):108049. doi: 10.1016/j.jbc.2024.108049. Online ahead of print. J Biol Chem. 2024. PMID: 39638245 Free article.
Early childhood body mass index growth and school readiness: A longitudinal cohort study.
Li X, Kahane A, Keown-Stoneman CDG, Omand JA, Borkhoff CM, Lebovic G, Maguire JL, Mamdani M, Parkin PC, Simpson JR, Tremblay MS, Vanderloo LM, Duku E, Reid-Westoby C, Janus M, Birken CS; TARGet Kids! Collaboration. Li X, et al. Paediatr Perinat Epidemiol. 2024 Nov;38(8):733-744. doi: 10.1111/ppe.13114. Paediatr Perinat Epidemiol. 2024. PMID: 39607066
952 results