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The lysosomal v-ATPase-Ragulator complex is a common activator for AMPK and mTORC1, acting as a switch between catabolism and anabolism.
Zhang CS, Jiang B, Li M, Zhu M, Peng Y, Zhang YL, Wu YQ, Li TY, Liang Y, Lu Z, Lian G, Liu Q, Guo H, Yin Z, Ye Z, Han J, Wu JW, Yin H, Lin SY, Lin SC. Zhang CS, et al. Among authors: wu yq, wu jw. Cell Metab. 2014 Sep 2;20(3):526-40. doi: 10.1016/j.cmet.2014.06.014. Epub 2014 Jul 4. Cell Metab. 2014. PMID: 25002183 Free article.
ULK1/2 Constitute a Bifurcate Node Controlling Glucose Metabolic Fluxes in Addition to Autophagy.
Li TY, Sun Y, Liang Y, Liu Q, Shi Y, Zhang CS, Zhang C, Song L, Zhang P, Zhang X, Li X, Chen T, Huang HY, He X, Wang Y, Wu YQ, Chen S, Jiang M, Chen C, Xie C, Yang JY, Lin Y, Zhao S, Ye Z, Lin SY, Chiu DT, Lin SC. Li TY, et al. Among authors: wu yq. Mol Cell. 2016 May 5;62(3):359-370. doi: 10.1016/j.molcel.2016.04.009. Mol Cell. 2016. PMID: 27153534 Free article.
Metformin Activates AMPK through the Lysosomal Pathway.
Zhang CS, Li M, Ma T, Zong Y, Cui J, Feng JW, Wu YQ, Lin SY, Lin SC. Zhang CS, et al. Among authors: wu yq. Cell Metab. 2016 Oct 11;24(4):521-522. doi: 10.1016/j.cmet.2016.09.003. Cell Metab. 2016. PMID: 27732831 Free article. No abstract available.
Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK.
Zhang CS, Hawley SA, Zong Y, Li M, Wang Z, Gray A, Ma T, Cui J, Feng JW, Zhu M, Wu YQ, Li TY, Ye Z, Lin SY, Yin H, Piao HL, Hardie DG, Lin SC. Zhang CS, et al. Among authors: wu yq. Nature. 2017 Aug 3;548(7665):112-116. doi: 10.1038/nature23275. Epub 2017 Jul 19. Nature. 2017. PMID: 28723898 Free PMC article.
Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK.
Li M, Zhang CS, Zong Y, Feng JW, Ma T, Hu M, Lin Z, Li X, Xie C, Wu Y, Jiang D, Li Y, Zhang C, Tian X, Wang W, Yang Y, Chen J, Cui J, Wu YQ, Chen X, Liu QF, Wu J, Lin SY, Ye Z, Liu Y, Piao HL, Yu L, Zhou Z, Xie XS, Hardie DG, Lin SC. Li M, et al. Among authors: wu y, wu yq, wu j. Cell Metab. 2019 Sep 3;30(3):508-524.e12. doi: 10.1016/j.cmet.2019.05.018. Epub 2019 Jun 13. Cell Metab. 2019. PMID: 31204282 Free PMC article.
Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate.
Wu YQ, Zhang CS, Xiong J, Cai DQ, Wang CZ, Wang Y, Liu YH, Wang Y, Li Y, Wu J, Wu J, Lan B, Wang X, Chen S, Cao X, Wei X, Hu HH, Guo H, Yu Y, Ghafoor A, Xie C, Wu Y, Xu Z, Zhang C, Zhu M, Huang X, Sun X, Lin SY, Piao HL, Zhou J, Lin SC. Wu YQ, et al. Among authors: wu y, wu j. Cell Res. 2023 Nov;33(11):835-850. doi: 10.1038/s41422-023-00874-4. Epub 2023 Sep 19. Cell Res. 2023. PMID: 37726403 Free PMC article.
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