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19,859 results

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Identification of Pyrrolo[2,3- d]pyrimidine-Based Derivatives as Potent and Orally Effective Fms-like Tyrosine Receptor Kinase 3 (FLT3) Inhibitors for Treating Acute Myelogenous Leukemia.
Yuan X, Chen Y, Zhang W, He J, Lei L, Tang M, Liu J, Li M, Dou C, Yang T, Yang L, Yang S, Wei Y, Peng A, Niu T, Xiang M, Ye H, Chen L. Yuan X, et al. Among authors: yang s, yang t, yang l. J Med Chem. 2019 Apr 25;62(8):4158-4173. doi: 10.1021/acs.jmedchem.9b00223. Epub 2019 Apr 15. J Med Chem. 2019. PMID: 30939008
Discovery of a Teraryl Oxazolidinone Compound (S)-N-((3-(3-Fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide Phosphate as a Novel Antimicrobial Agent with Enhanced Safety Profile and Efficacies.
Yang T, Chen G, Sang Z, Liu Y, Yang X, Chang Y, Long H, Ang W, Tang J, Wang Z, Li G, Yang S, Zhang J, Wei Y, Luo Y. Yang T, et al. Among authors: yang s, yang x. J Med Chem. 2015 Aug 27;58(16):6389-409. doi: 10.1021/acs.jmedchem.5b00152. Epub 2015 Aug 17. J Med Chem. 2015. PMID: 26212502
Design, Synthesis, and Evaluation of in Vitro and in Vivo Anticancer Activity of 4-Substituted Coumarins: A Novel Class of Potent Tubulin Polymerization Inhibitors.
Cao D, Liu Y, Yan W, Wang C, Bai P, Wang T, Tang M, Wang X, Yang Z, Ma B, Ma L, Lei L, Wang F, Xu B, Zhou Y, Yang T, Chen L. Cao D, et al. Among authors: yang t, yang z. J Med Chem. 2016 Jun 23;59(12):5721-39. doi: 10.1021/acs.jmedchem.6b00158. Epub 2016 Jun 2. J Med Chem. 2016. PMID: 27213819
The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in β-tubulin.
Yang J, Yan W, Yu Y, Wang Y, Yang T, Xue L, Yuan X, Long C, Liu Z, Chen X, Hu M, Zheng L, Qiu Q, Pei H, Li D, Wang F, Bai P, Wen J, Ye H, Chen L. Yang J, et al. Among authors: yang t. J Biol Chem. 2018 Jun 15;293(24):9461-9472. doi: 10.1074/jbc.RA117.001658. Epub 2018 Apr 24. J Biol Chem. 2018. PMID: 29691282 Free PMC article.
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