Varma MVS - Search Results

1

Clopidogrel as a Perpetrator of Drug-Drug Interactions: A Challenge for Quantitative Predictions?

Varma MVS, Bi YA, Lazzaro S, West M. Varma MVS, et al. Clin Pharmacol Ther. 2019 Jun;105(6):1295-1299. doi: 10.1002/cpt.1398. Epub 2019 Mar 30. Clin Pharmacol Ther. 2019. PMID: 30927478 Review. No abstract available.

2

Mechanistic modeling to predict the transporter- and enzyme-mediated drug-drug interactions of repaglinide.

Varma MV, Lai Y, Kimoto E, Goosen TC, El-Kattan AF, Kumar V. Varma MV, et al. Pharm Res. 2013 Apr;30(4):1188-99. doi: 10.1007/s11095-012-0956-5. Epub 2013 Jan 10. Pharm Res. 2013. PMID: 23307347

3

Quantitative prediction of repaglinide-rifampicin complex drug interactions using dynamic and static mechanistic models: delineating differential CYP3A4 induction and OATP1B1 inhibition potential of rifampicin.

Varma MV, Lin J, Bi YA, Rotter CJ, Fahmi OA, Lam JL, El-Kattan AF, Goosen TC, Lai Y. Varma MV, et al. Drug Metab Dispos. 2013 May;41(5):966-74. doi: 10.1124/dmd.112.050583. Epub 2013 Feb 7. Drug Metab Dispos. 2013. PMID: 23393219

4

Elucidation of the biochemical basis for a clinical drug-drug interaction between atorvastatin and 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778875), a subtype selective agonist of the peroxisome proliferator-activated receptor alpha.

Kalgutkar AS, Chen D, Varma MV, Feng B, Terra SG, Scialis RJ, Rotter CJ, Frederick KS, West MA, Goosen TC, Gosset JR, Walsky RL, Francone OL. Kalgutkar AS, et al. Xenobiotica. 2013 Nov;43(11):963-72. doi: 10.3109/00498254.2013.791004. Epub 2013 Apr 30. Xenobiotica. 2013. PMID: 23631744

5

Quantitative assessment of the contribution of sodium-dependent taurocholate co-transporting polypeptide (NTCP) to the hepatic uptake of rosuvastatin, pitavastatin and fluvastatin.

Bi YA, Qiu X, Rotter CJ, Kimoto E, Piotrowski M, Varma MV, Ei-Kattan AF, Lai Y. Bi YA, et al. Biopharm Drug Dispos. 2013 Nov;34(8):452-61. doi: 10.1002/bdd.1861. Epub 2013 Oct 3. Biopharm Drug Dispos. 2013. PMID: 23996477

6

Mechanism-based pharmacokinetic modeling to evaluate transporter-enzyme interplay in drug interactions and pharmacogenetics of glyburide.

Varma MV, Scialis RJ, Lin J, Bi YA, Rotter CJ, Goosen TC, Yang X. Varma MV, et al. AAPS J. 2014 Jul;16(4):736-48. doi: 10.1208/s12248-014-9614-7. Epub 2014 May 17. AAPS J. 2014. PMID: 24839071 Free PMC article.

7

Quantitative prediction of transporter- and enzyme-mediated clinical drug-drug interactions of organic anion-transporting polypeptide 1B1 substrates using a mechanistic net-effect model.

Varma MV, Bi YA, Kimoto E, Lin J. Varma MV, et al. J Pharmacol Exp Ther. 2014 Oct;351(1):214-23. doi: 10.1124/jpet.114.215970. Epub 2014 Aug 8. J Pharmacol Exp Ther. 2014. PMID: 25107633

8

Dealing with the complex drug-drug interactions: towards mechanistic models.

Varma MV, Pang KS, Isoherranen N, Zhao P. Varma MV, et al. Biopharm Drug Dispos. 2015 Mar;36(2):71-92. doi: 10.1002/bdd.1934. Epub 2015 Feb 10. Biopharm Drug Dispos. 2015. PMID: 25545151 Review.

9

Quantitative Rationalization of Gemfibrozil Drug Interactions: Consideration of Transporters-Enzyme Interplay and the Role of Circulating Metabolite Gemfibrozil 1-O-β-Glucuronide.

Varma MV, Lin J, Bi YA, Kimoto E, Rodrigues AD. Varma MV, et al. Drug Metab Dispos. 2015 Jul;43(7):1108-18. doi: 10.1124/dmd.115.064303. Epub 2015 May 4. Drug Metab Dispos. 2015. PMID: 25941268

10

The Antimicrobial Agent Fusidic Acid Inhibits Organic Anion Transporting Polypeptide-Mediated Hepatic Clearance and May Potentiate Statin-Induced Myopathy.

Eng H, Scialis RJ, Rotter CJ, Lin J, Lazzaro S, Varma MV, Di L, Feng B, West M, Kalgutkar AS. Eng H, et al. Drug Metab Dispos. 2016 May;44(5):692-9. doi: 10.1124/dmd.115.067447. Epub 2016 Feb 17. Drug Metab Dispos. 2016. PMID: 26888941

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