Walton T - Search Results

1

The Mechanism of Nonenzymatic Template Copying with Imidazole-Activated Nucleotides.

Walton T, Zhang W, Li L, Tam CP, Szostak JW. Walton T, et al. Angew Chem Int Ed Engl. 2019 Aug 5;58(32):10812-10819. doi: 10.1002/anie.201902050. Epub 2019 Jul 4. Angew Chem Int Ed Engl. 2019. PMID: 30908802 Review.

2

A Highly Reactive Imidazolium-Bridged Dinucleotide Intermediate in Nonenzymatic RNA Primer Extension.

Walton T, Szostak JW. Walton T, et al. J Am Chem Soc. 2016 Sep 14;138(36):11996-2002. doi: 10.1021/jacs.6b07977. Epub 2016 Sep 1. J Am Chem Soc. 2016. PMID: 27552367 Free PMC article.

3

Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex.

Zhang W, Tam CP, Walton T, Fahrenbach AC, Birrane G, Szostak JW. Zhang W, et al. Among authors: walton t. Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):7659-7664. doi: 10.1073/pnas.1704006114. Epub 2017 Jul 3. Proc Natl Acad Sci U S A. 2017. PMID: 28673998 Free PMC article.

4

A Kinetic Model of Nonenzymatic RNA Polymerization by Cytidine-5'-phosphoro-2-aminoimidazolide.

Walton T, Szostak JW. Walton T, et al. Biochemistry. 2017 Oct 31;56(43):5739-5747. doi: 10.1021/acs.biochem.7b00792. Epub 2017 Oct 19. Biochemistry. 2017. PMID: 29022704 Free PMC article.

5

Synthesis of a Nonhydrolyzable Nucleotide Phosphoroimidazolide Analogue That Catalyzes Nonenzymatic RNA Primer Extension.

Tam CP, Zhou L, Fahrenbach AC, Zhang W, Walton T, Szostak JW. Tam CP, et al. Among authors: walton t. J Am Chem Soc. 2018 Jan 17;140(2):783-792. doi: 10.1021/jacs.7b11623. Epub 2018 Jan 2. J Am Chem Soc. 2018. PMID: 29251930 Free PMC article.

6

Crystallographic observation of nonenzymatic RNA primer extension.

Zhang W, Walton T, Li L, Szostak JW. Zhang W, et al. Among authors: walton t. Elife. 2018 May 31;7:e36422. doi: 10.7554/eLife.36422. Elife. 2018. PMID: 29851379 Free PMC article.

7

Template-Directed Catalysis of a Multistep Reaction Pathway for Nonenzymatic RNA Primer Extension.

Walton T, Pazienza L, Szostak JW. Walton T, et al. Biochemistry. 2019 Feb 12;58(6):755-762. doi: 10.1021/acs.biochem.8b01156. Epub 2018 Dec 31. Biochemistry. 2019. PMID: 30566332 Free PMC article.

8

In vitro selection of ribozyme ligases that use prebiotically plausible 2-aminoimidazole-activated substrates.

Walton T, DasGupta S, Duzdevich D, Oh SS, Szostak JW. Walton T, et al. Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):5741-5748. doi: 10.1073/pnas.1914367117. Epub 2020 Mar 2. Proc Natl Acad Sci U S A. 2020. PMID: 32123094 Free PMC article.

9

Competition between bridged dinucleotides and activated mononucleotides determines the error frequency of nonenzymatic RNA primer extension.

Duzdevich D, Carr CE, Ding D, Zhang SJ, Walton TS, Szostak JW. Duzdevich D, et al. Nucleic Acids Res. 2021 Apr 19;49(7):3681-3691. doi: 10.1093/nar/gkab173. Nucleic Acids Res. 2021. PMID: 33744957 Free PMC article.

10

Release of iron from C-terminal monoferric transferrin to phosphate and pyrophosphate at pH 5.5 proceeds through two pathways.

Marques HM, Walton T, Egan TJ. Marques HM, et al. Among authors: walton t. J Inorg Biochem. 1995 Jan;57(1):11-21. doi: 10.1016/0162-0134(94)00009-y. J Inorg Biochem. 1995. PMID: 7876832

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