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AP2M1 mediates autophagy-induced CLDN2 (claudin 2) degradation through endocytosis and interaction with LC3 and reduces intestinal epithelial tight junction permeability.
Ganapathy AS, Saha K, Suchanec E, Singh V, Verma A, Yochum G, Koltun W, Nighot M, Ma T, Nighot P. Ganapathy AS, et al. Among authors: suchanec e. Autophagy. 2022 Sep;18(9):2086-2103. doi: 10.1080/15548627.2021.2016233. Epub 2021 Dec 29. Autophagy. 2022. PMID: 34964704 Free PMC article.
Autophagy Reduces the Degradation and Promotes Membrane Localization of Occludin to Enhance the Intestinal Epithelial Tight Junction Barrier against Paracellular Macromolecule Flux.
Saha K, Subramenium Ganapathy A, Wang A, Michael Morris N, Suchanec E, Ding W, Yochum G, Koltun W, Nighot M, Ma T, Nighot P. Saha K, et al. Among authors: suchanec e. J Crohns Colitis. 2023 Apr 3;17(3):433-449. doi: 10.1093/ecco-jcc/jjac148. J Crohns Colitis. 2023. PMID: 36219473 Free PMC article.