Otrubova K - Search Results

1

N-Acyl pyrazoles: Effective and tunable inhibitors of serine hydrolases.

Otrubova K, Chatterjee S, Ghimire S, Cravatt BF, Boger DL. Otrubova K, et al. Bioorg Med Chem. 2019 Apr 15;27(8):1693-1703. doi: 10.1016/j.bmc.2019.03.020. Epub 2019 Mar 11. Bioorg Med Chem. 2019. PMID: 30879861 Free PMC article.

2

Fatty acid amide signaling molecules.

Ezzili C, Otrubova K, Boger DL. Ezzili C, et al. Among authors: otrubova k. Bioorg Med Chem Lett. 2010 Oct 15;20(20):5959-68. doi: 10.1016/j.bmcl.2010.08.048. Epub 2010 Aug 13. Bioorg Med Chem Lett. 2010. PMID: 20817522 Free PMC article. Review.

3

The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).

Otrubova K, Ezzili C, Boger DL. Otrubova K, et al. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4674-85. doi: 10.1016/j.bmcl.2011.06.096. Epub 2011 Jun 28. Bioorg Med Chem Lett. 2011. PMID: 21764305 Free PMC article. Review.

4

Rational design of fatty acid amide hydrolase inhibitors that act by covalently bonding to two active site residues.

Otrubova K, Brown M, McCormick MS, Han GW, O'Neal ST, Cravatt BF, Stevens RC, Lichtman AH, Boger DL. Otrubova K, et al. J Am Chem Soc. 2013 Apr 24;135(16):6289-99. doi: 10.1021/ja4014997. Epub 2013 Apr 12. J Am Chem Soc. 2013. PMID: 23581831 Free PMC article.

5

Design, synthesis, and characterization of α-ketoheterocycles that additionally target the cytosolic port Cys269 of fatty acid amide hydrolase.

Otrubova K, Cravatt BF, Boger DL. Otrubova K, et al. J Med Chem. 2014 Feb 13;57(3):1079-89. doi: 10.1021/jm401820q. Epub 2014 Jan 23. J Med Chem. 2014. PMID: 24456116 Free PMC article.

6

α-Ketoheterocycle inhibitors of fatty acid amide hydrolase: exploration of conformational constraints in the acyl side chain.

Duncan KK, Otrubova K, Boger DL. Duncan KK, et al. Among authors: otrubova k. Bioorg Med Chem. 2014 May 1;22(9):2763-70. doi: 10.1016/j.bmc.2014.03.013. Epub 2014 Mar 18. Bioorg Med Chem. 2014. PMID: 24690529 Free PMC article.

7

Discovery libraries targeting the major enzyme classes: the serine hydrolases.

Otrubova K, Srinivasan V, Boger DL. Otrubova K, et al. Bioorg Med Chem Lett. 2014 Aug 15;24(16):3807-13. doi: 10.1016/j.bmcl.2014.06.063. Epub 2014 Jun 27. Bioorg Med Chem Lett. 2014. PMID: 25037918 Free PMC article.

8

α-Ketoheterocycle-based Inhibitors of Fatty Acid Amide Hydrolase (FAAH).

Otrubova K, Boger DL. Otrubova K, et al. ACS Chem Neurosci. 2012 May 16;3(5):340-348. doi: 10.1021/cn2001206. Epub 2011 Dec 20. ACS Chem Neurosci. 2012. PMID: 22639704 Free PMC article.

9

Potent Vinblastine C20' Ureas Displaying Additionally Improved Activity Against a Vinblastine-Resistant Cancer Cell Line.

Barker TJ, Duncan KK, Otrubova K, Boger DL. Barker TJ, et al. Among authors: otrubova k. ACS Med Chem Lett. 2013 Sep 9;4(10):985-8. doi: 10.1021/ml400281w. ACS Med Chem Lett. 2013. PMID: 24223237 Free PMC article.

10

Synthesis of Sansalvamide A derivatives and their cytotoxicity in the MSS colon cancer cell line HT-29.

Styers TJ, Kekec A, Rodriguez R, Brown JD, Cajica J, Pan PS, Parry E, Carroll CL, Medina I, Corral R, Lapera S, Otrubova K, Pan CM, McGuire KL, McAlpine SR. Styers TJ, et al. Among authors: otrubova k. Bioorg Med Chem. 2006 Aug 15;14(16):5625-31. doi: 10.1016/j.bmc.2006.04.031. Epub 2006 May 11. Bioorg Med Chem. 2006. PMID: 16697205

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